| Literature DB >> 16911840 |
Jin Hee Kim1, Mira Park, So Young Yang, Bum Seok Jeong, Hee Jeong Yoo, Jong-Woo Kim, Joo-Ho Chung, Soon Ae Kim.
Abstract
The N-methyl-D-aspartate (NMDA) receptor 2B gene (GRIN2B) was studied as a candidate gene of alcoholism. This study aimed to investigate the association between each of the three GRIN2B polymorphisms (rs1806201, rs1805247, and rs1805502) and alcoholism. This study included 206 alcoholic patients and 189 unrelated control subjects of Korean origin. Associations between genotype, allele, and haplotype frequencies of the polymorphisms and alcoholism were investigated. The genotype frequencies of rs1806201 and the haplotype analysis of SNPs in this study show significantly differences between the case and controls. These findings suggest new candidate SNPs in GRIN2B for studying the genetic susceptibility to alcoholism.Entities:
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Year: 2006 PMID： 16911840 DOI： 10.1016/j.neures.2006.06.013
Source DB: PubMed Journal: Neurosci Res ISSN： 0168-0102 Impact factor: 3.304