Literature DB >> 1691162

Carcinogenicity of 2-amino-3-methylimidazo[4,5-f]quinoline in nonhuman primates: induction of tumors in three macaques.

R H Adamson1, U P Thorgeirsson, E G Snyderwine, S S Thorgeirsson, J Reeves, D W Dalgard, S Takayama, T Sugimura.   

Abstract

The carcinogenic potential of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) was evaluated in cynomolgus monkeys. Monkeys received IQ, beginning at the age of one year, at doses of 10 or 20 mg/kg by gavage. Thus far, IQ has induced hepatocellular carcinoma in three monkeys with a latent period of 27 to 37 months. Metastases to the lung occurred in two of the three monkeys. Microscopically, the hepatocellular carcinoma in all three cases demonstrated a trabecular pattern. These data demonstrate that IQ is a potent carcinogen in nonhuman primates and support the idea that it is a potential carcinogen for humans.

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Year:  1990        PMID： 1691162      PMCID： PMC5917955          DOI： 10.1111/j.1349-7006.1990.tb02500.x

Source DB:  PubMed          Journal:  Jpn J Cancer Res        ISSN： 0910-5050


  3 in total

1.  Carcinogenicity of mutagenic heterocyclic amines formed during the cooking process.

Authors:  T Sugimura
Journal:  Mutat Res       Date:  1985 Jun-Jul       Impact factor: 2.433

2.  Demonstration of carcinogenicity in F344 rats of 2-amino-3-methyl-imidazo[4,5-f]quinoline from broiled sardine, fried beef and beef extract.

Authors:  S Takayama; Y Nakatsuru; M Masuda; H Ohgaki; S Sato; T Sugimura
Journal:  Gan       Date:  1984-06

3.  Carcinogenicity in mice of a mutagenic compound, 2-amino-3-methylimidazo[4,5-f]quinoline, from broiled sardine, cooked beef and beef extract.

Authors:  H Ohgaki; K Kusama; N Matsukura; K Morino; H Hasegawa; S Sato; S Takayama; T Sugimura
Journal:  Carcinogenesis       Date:  1984-07       Impact factor: 4.944
  3 in total
  28 in total

1.  Rat p53 gene mutations in primary Zymbal gland tumors induced by 2-amino-3-methylimidazo[4,5-f]quinoline, a food mutagen.

Authors:  H Makino; Y Ishizaka; A Tsujimoto; T Nakamura; M Onda; T Sugimura; M Nagao
Journal:  Proc Natl Acad Sci U S A       Date:  1992-06-01       Impact factor: 11.205

2.  Base-displaced intercalated structure of the food mutagen 2-amino-3-methylimidazo[4,5-f]quinoline in the recognition sequence of the NarI restriction enzyme, a hotspot for -2 bp deletions.

Authors:  Feng Wang; Nicholas E DeMuro; C Eric Elmquist; James S Stover; Carmelo J Rizzo; Michael P Stone
Journal:  J Am Chem Soc       Date:  2006-08-09       Impact factor: 15.419

Review 3.  Metabolism and biomarkers of heterocyclic aromatic amines in molecular epidemiology studies: lessons learned from aromatic amines.

Authors:  Robert J Turesky; Loic Le Marchand
Journal:  Chem Res Toxicol       Date:  2011-06-20       Impact factor: 3.739

4.  Role of N-acetyltransferase polymorphisms in hepatitis B related hepatocellular carcinoma: impact of smoking on risk.

Authors:  M W Yu; C I Pai; S Y Yang; T J Hsiao; H C Chang; S M Lin; Y F Liaw; P J Chen; C J Chen
Journal:  Gut       Date:  2000-11       Impact factor: 23.059

5.  Characterization of new metabolites from in vivo biotransformation of 2-amino-3-methylimidazo[4,5-f]quinoline in mouse by mass spectrometry.

Authors:  Fong-Fu Hsu; Vijaya M Lakshmi; Terry V Zenser
Journal:  J Mass Spectrom       Date:  2009-09       Impact factor: 1.982

6.  Colon cancer incidence: recent trends in the United States.

Authors:  W H Chow; S S Devesa; W J Blot
Journal:  Cancer Causes Control       Date:  1991-11       Impact factor: 2.506

7.  Prostaglandin-H synthase mediated metabolism and mutagenic activation of 2-amino-3-methylimidazo [4,5-f] quinoline (IQ).

Authors:  E Wolz; D Wild; G H Degen
Journal:  Arch Toxicol       Date:  1995       Impact factor: 5.153

8.  Protective effects of epigallocatechin gallate on colon preneoplastic lesions induced by 2-amino-3-methylimidazo[4,5-f ] quinoline in mice.

Authors:  Jun-Hua Yuan; Yan-Qing Li; Xiao-Yun Yang
Journal:  Mol Med       Date:  2008 Sep-Oct       Impact factor: 6.354

Review 9.  Mouse models for the study of colon carcinogenesis.

Authors:  Daniel W Rosenberg; Charles Giardina; Takuji Tanaka
Journal:  Carcinogenesis       Date:  2008-11-26       Impact factor: 4.944

10.  Meat and meat-related compounds and risk of prostate cancer in a large prospective cohort study in the United States.

Authors:  Rashmi Sinha; Yikyung Park; Barry I Graubard; Michael F Leitzmann; Albert Hollenbeck; Arthur Schatzkin; Amanda J Cross
Journal:  Am J Epidemiol       Date:  2009-10-06       Impact factor: 4.897
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