Literature DB >> 6468834

Demonstration of carcinogenicity in F344 rats of 2-amino-3-methyl-imidazo[4,5-f]quinoline from broiled sardine, fried beef and beef extract.

S Takayama, Y Nakatsuru, M Masuda, H Ohgaki, S Sato, T Sugimura.   

Abstract

The mutagenic compound 2-amino-3-methylimidazo[4,5-f]quinoline, originally isolated from broiled sardines and also present in cooked beef and beef extract, is being tested for carcinogenicity in F344 rats of both sexes. High incidences of tumors of the Zymbal gland, colon, small intestine and liver in males have been observed in the first 300 days of the experiment.

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Year:  1984        PMID： 6468834

Source DB:  PubMed          Journal:  Gan        ISSN： 0016-450X


  31 in total

1.  Monoclonal antibody to 2-amino-3-methylimidazo(4,5-f)quinoline, a dietary carcinogen.

Authors:  H Yanagisawa; T Tachikawa; S Shin; O Wada
Journal:  Appl Biochem Biotechnol       Date:  1990-01       Impact factor: 2.926

2.  Base-displaced intercalated structure of the food mutagen 2-amino-3-methylimidazo[4,5-f]quinoline in the recognition sequence of the NarI restriction enzyme, a hotspot for -2 bp deletions.

Authors:  Feng Wang; Nicholas E DeMuro; C Eric Elmquist; James S Stover; Carmelo J Rizzo; Michael P Stone
Journal:  J Am Chem Soc       Date:  2006-08-09       Impact factor: 15.419

3.  Activation of rat c-raf during transfection of hepatocellular carcinoma DNA.

Authors:  F Ishikawa; F Takaku; K Hayashi; M Nagao; T Sugimura
Journal:  Proc Natl Acad Sci U S A       Date:  1986-05       Impact factor: 11.205

4.  Role of N-acetyltransferase polymorphisms in hepatitis B related hepatocellular carcinoma: impact of smoking on risk.

Authors:  M W Yu; C I Pai; S Y Yang; T J Hsiao; H C Chang; S M Lin; Y F Liaw; P J Chen; C J Chen
Journal:  Gut       Date:  2000-11       Impact factor: 23.059

5.  The consumption of well-done red meat and the risk of colorectal cancer.

Authors:  J E Muscat; E L Wynder
Journal:  Am J Public Health       Date:  1994-05       Impact factor: 9.308

6.  Prostaglandin-H synthase mediated metabolism and mutagenic activation of 2-amino-3-methylimidazo [4,5-f] quinoline (IQ).

Authors:  E Wolz; D Wild; G H Degen
Journal:  Arch Toxicol       Date:  1995       Impact factor: 5.153

7.  Mutagenic activation of 2-amino-3-methylimidazo[4,5-f]-quinoline (IQ) and 2-amino-3,4-dimethylimidazo[4,5-f]-quinoline (MeIQ) by subcellular fractions and cells isolated from small intestine, kidney and liver of the rat.

Authors:  J A Holme; J Alexander; E Dybing
Journal:  Cell Biol Toxicol       Date:  1987-03       Impact factor: 6.691

8.  DNA sequence modulates the conformation of the food mutagen 2-amino-3-methylimidazo[4,5-f]quinoline in the recognition sequence of the NarI restriction enzyme.

Authors:  Feng Wang; C Eric Elmquist; James S Stover; Carmelo J Rizzo; Michael P Stone
Journal:  Biochemistry       Date:  2007-06-30       Impact factor: 3.162

9.  Carcinogenicity in mice and rats of heterocyclic amines in cooked foods.

Authors:  H Ohgaki; H Hasegawa; T Kato; M Suenaga; M Ubukata; S Sato; S Takayama; T Sugimura
Journal:  Environ Health Perspect       Date:  1986-08       Impact factor: 9.031

10.  Use of blue cotton for detection of mutagenicity in human feces excreted after ingestion of cooked meat.

Authors:  H Hayatsu; T Hayatsu; Y Wataya
Journal:  Environ Health Perspect       Date:  1986-08       Impact factor: 9.031
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