Literature DB >> 16909399

Schizophrenia and oxidative stress: glutamate cysteine ligase modifier as a susceptibility gene.

Mirjana Tosic1, Jurg Ott, Sandra Barral, Pierre Bovet, Patricia Deppen, Fulvia Gheorghita, Marie-Louise Matthey, Josef Parnas, Martin Preisig, Michael Saraga, Alessandra Solida, Sally Timm, August G Wang, Thomas Werge, Michel Cuénod, Kim Quang Do.   

Abstract

Oxidative stress could be involved in the pathophysiology of schizophrenia, a major psychiatric disorder. Glutathione (GSH), a redox regulator, is decreased in patients' cerebrospinal fluid and prefrontal cortex. The gene of the key GSH-synthesizing enzyme, glutamate cysteine ligase modifier (GCLM) subunit, is strongly associated with schizophrenia in two case-control studies and in one family study. GCLM gene expression is decreased in patients' fibroblasts. Thus, GSH metabolism dysfunction is proposed as one of the vulnerability factors for schizophrenia.

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Year:  2006        PMID： 16909399      PMCID： PMC1559555          DOI： 10.1086/507566

Source DB:  PubMed          Journal:  Am J Hum Genet        ISSN： 0002-9297            Impact factor:   11.025


  38 in total

1.  Lamina-specific reductions in dendritic spine density in the prefrontal cortex of subjects with schizophrenia.

Authors:  Nutan Kolluri; Zhuoxin Sun; Allan R Sampson; David A Lewis
Journal:  Am J Psychiatry       Date:  2005-06       Impact factor: 18.112

2.  Mapping of the glutamate-cysteine ligase catalytic subunit gene (GLCLC) to human chromosome 6p12 and mouse chromosome 9D-E and of the regulatory subunit gene (GLCLR) to human chromosome 1p21-p22 and mouse chromosome 3H1-3.

Authors:  K Tsuchiya; R T Mulcahy; L L Reid; C M Disteche; T J Kavanagh
Journal:  Genomics       Date:  1995-12-10       Impact factor: 5.736

3.  Glutamate cysteine ligase catalysis: dependence on ATP and modifier subunit for regulation of tissue glutathione levels.

Authors:  Ying Chen; Howard G Shertzer; Scott N Schneider; Daniel W Nebert; Timothy P Dalton
Journal:  J Biol Chem       Date:  2005-08-04       Impact factor: 5.157

4.  Synaptic plasticity impairment and hypofunction of NMDA receptors induced by glutathione deficit: relevance to schizophrenia.

Authors:  P Steullet; H C Neijt; M Cuénod; K Q Do
Journal:  Neuroscience       Date:  2005-12-05       Impact factor: 3.590

Review 5.  Cortical inhibitory neurons and schizophrenia.

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Journal:  Nat Rev Neurosci       Date:  2005-04       Impact factor: 34.870

6.  Genomewide high-density SNP linkage analysis of 236 Japanese families supports the existence of schizophrenia susceptibility loci on chromosomes 1p, 14q, and 20p.

Authors:  Tadao Arinami; Tsuyuka Ohtsuki; Hiroki Ishiguro; Hiroshi Ujike; Yuji Tanaka; Yukitaka Morita; Mari Mineta; Masashi Takeichi; Shigeto Yamada; Akira Imamura; Koichi Ohara; Haruo Shibuya; Kenshiro Ohara; Yasuo Suzuki; Tatsuyuki Muratake; Naoshi Kaneko; Toshiyuki Someya; Toshiya Inada; Takeo Yoshikawa; Tomoko Toyota; Kazuo Yamada; Takuya Kojima; Sakae Takahashi; Ohmori Osamu; Takahiro Shinkai; Michiko Nakamura; Hiroshi Fukuzako; Tomo Hashiguchi; Shin-ich Niwa; Takuya Ueno; Hirokazu Tachikawa; Takafumi Hori; Takashi Asada; Shinichiro Nanko; Hiroshi Kunugi; Ryota Hashimoto; Norio Ozaki; Nakao Iwata; Mutsuo Harano; Heii Arai; Tohru Ohnuma; Ichiro Kusumi; Tsukasa Koyama; Hiroshi Yoneda; Yasuyuki Fukumaki; Hiroki Shibata; Sunao Kaneko; Hisashi Higuchi; Norio Yasui-Furukori; Yohtaro Numachi; Masanari Itokawa; Yuji Okazaki
Journal:  Am J Hum Genet       Date:  2005-10-12       Impact factor: 11.025

7.  Deficient hippocampal neuron expression of proteasome, ubiquitin, and mitochondrial genes in multiple schizophrenia cohorts.

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8.  gamma-Glutamylglutamine and taurine concentrations are decreased in the cerebrospinal fluid of drug-naive patients with schizophrenic disorders.

Authors:  K Q Do; C J Lauer; W Schreiber; M Zollinger; U Gutteck-Amsler; M Cuénod; F Holsboer
Journal:  J Neurochem       Date:  1995-12       Impact factor: 5.372

9.  Role of endogenous glutathione in the oxidation of dopamine.

Authors:  A D Rabinovic; T G Hastings
Journal:  J Neurochem       Date:  1998-11       Impact factor: 5.372

10.  Altered glutathione redox state in schizophrenia.

Authors:  Jeffrey K Yao; Sherry Leonard; Ravinder Reddy
Journal:  Dis Markers       Date:  2006       Impact factor: 3.434
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  73 in total

1.  Meta-analysis of the efficacy of adjunctive NMDA receptor modulators in chronic schizophrenia.

Authors:  Surendra P Singh; Vidhi Singh
Journal:  CNS Drugs       Date:  2011-10-01       Impact factor: 5.749

Review 2.  Genetic association studies of antioxidant pathway genes and schizophrenia.

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Journal:  Antioxid Redox Signal       Date:  2010-11-01       Impact factor: 8.401

3.  Pilot study on schizophrenia in Sardinia.

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4.  Glutathione deficit impairs myelin maturation: relevance for white matter integrity in schizophrenia patients.

Authors:  A Monin; P S Baumann; A Griffa; L Xin; R Mekle; M Fournier; C Butticaz; M Klaey; J H Cabungcal; P Steullet; C Ferrari; M Cuenod; R Gruetter; J P Thiran; P Hagmann; P Conus; K Q Do
Journal:  Mol Psychiatry       Date:  2014-08-26       Impact factor: 15.992

Review 5.  Oxidative stress in schizophrenia: an integrated approach.

Authors:  Byron K Y Bitanihirwe; Tsung-Ung W Woo
Journal:  Neurosci Biobehav Rev       Date:  2010-10-23       Impact factor: 8.989

6.  Is bipolar disorder a mitochondrial disease?

Authors:  L Trevor Young
Journal:  J Psychiatry Neurosci       Date:  2007-05       Impact factor: 6.186

7.  Genotype patterns that contribute to increased risk for or protection from developing heroin addiction.

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Journal:  Mol Psychiatry       Date:  2008-01-15       Impact factor: 15.992

Review 8.  Structure, function, and post-translational regulation of the catalytic and modifier subunits of glutamate cysteine ligase.

Authors:  Christopher C Franklin; Donald S Backos; Isaac Mohar; Collin C White; Henry J Forman; Terrance J Kavanagh
Journal:  Mol Aspects Med       Date:  2008-09-06

9.  A comparative 90-day toxicity study of allyl acetate, allyl alcohol and acrolein.

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Review 10.  Neurodegenerative aspects in vulnerability to schizophrenia spectrum disorders.

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Journal:  Neurotox Res       Date:  2014-05-08       Impact factor: 3.911
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