BACKGROUND: Lung disease is a major cause of morbidity and death in sickle cell disease. Although airway hyperresponsiveness has been noted in children, there are no studies in adult sickle cell patients. The aim of this study was to investigate the prevalence of airway hyperresponsiveness in adult sickle cell patients. METHODS: Twenty-six patients with sickle cell disease (10 HbSC, 9 HbSS, and 7 HbSbeta) were compared with 28 normal control subjects. Pulmonary function tests, including spirometry, measurements of single-breath diffusing capacity and the methacholine challenge test were performed. RESULTS: There were no significant differences in age, gender, or height between groups. Restrictive ventilatory defect was observed in six patients (24%) in the sickle cell disease group. Obstructive ventilatory defect and reduced diffusing lung DLCO capacity was observed in all sickle cell disease subgroups. A positive methacholine challenge test was obtained in eight (31%) sickle cell patients and in two of the 28 controls (7%). CONCLUSION: These features suggest that there is a high prevalence of airway hyperresponsiveness in adult patients with sickle cell disease without a history of reactive airway disease.
BACKGROUND:Lung disease is a major cause of morbidity and death in sickle cell disease. Although airway hyperresponsiveness has been noted in children, there are no studies in adult sickle cell patients. The aim of this study was to investigate the prevalence of airway hyperresponsiveness in adult sickle cell patients. METHODS: Twenty-six patients with sickle cell disease (10 HbSC, 9 HbSS, and 7 HbSbeta) were compared with 28 normal control subjects. Pulmonary function tests, including spirometry, measurements of single-breath diffusing capacity and the methacholine challenge test were performed. RESULTS: There were no significant differences in age, gender, or height between groups. Restrictive ventilatory defect was observed in six patients (24%) in the sickle cell disease group. Obstructive ventilatory defect and reduced diffusing lung DLCO capacity was observed in all sickle cell disease subgroups. A positive methacholine challenge test was obtained in eight (31%) sickle cell patients and in two of the 28 controls (7%). CONCLUSION: These features suggest that there is a high prevalence of airway hyperresponsiveness in adult patients with sickle cell disease without a history of reactive airway disease.
Authors: Biree Andemariam; Alexander J Adami; Anurag Singh; Jeffrey T McNamara; Eric R Secor; Linda A Guernsey; Roger S Thrall Journal: Transl Res Date: 2015-03-16 Impact factor: 7.012
Authors: Marthe-Sandrine Eiymo Mwa Mpollo; Eric B Brandt; Shiva Kumar Shanmukhappa; Paritha I Arumugam; Swati Tiwari; Anastacia Loberg; Devin Pillis; Tilat Rizvi; Mark Lindsey; Bart Jonck; Peter Carmeliet; Vijay K Kalra; Timothy D Le Cras; Nancy Ratner; Marsha Wills-Karp; Gurjit K Khurana Hershey; Punam Malik Journal: J Clin Invest Date: 2015-12-21 Impact factor: 14.808
Authors: Joshua J Field; Jeffrey Glassberg; Annette Gilmore; Joanna Howard; Sameer Patankar; Yan Yan; Sally C Davies; Michael R Debaun; Robert C Strunk Journal: Am J Hematol Date: 2008-07 Impact factor: 10.047
Authors: Najibah A Galadanci; Wayne H Liang; Aisha A Galadanci; Muktar H Aliyu; Binta W Jibir; Ibraheem M Karaye; Baba P Inusa; Sten H Vermund; Robert C Strunk; Michael R DeBaun Journal: J Pediatr Hematol Oncol Date: 2015-01 Impact factor: 1.289