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Literature DB >> 18383325

Longitudinal analysis of pulmonary function in adults with sickle cell disease.

Joshua J Field¹, Jeffrey Glassberg, Annette Gilmore, Joanna Howard, Sameer Patankar, Yan Yan, Sally C Davies, Michael R Debaun, Robert C Strunk.

Abstract

Among adults with sickle cell disease (SCD), pulmonary complications are a leading cause of death. Yet, the natural history of lung function in adults with SCD is not well established. We conducted a retrospective cohort study of adults with SCD who had repeated pulmonary function tests performed over 20 years of age. Ninety-two adults were included in this cohort. Rate of decline in FEV(1) for men and women with SCD was 49 cc/year (compared with 20-26 cc/year in the general population). Further studies are needed to identify factors which impact the rate of lung function decline in adults with SCD. (c) 2008 Wiley-Liss, Inc.

Entities: Chemical Disease Gene Species

Mesh：

Year: 2008 PMID： 18383325 PMCID： PMC3729267 DOI： 10.1002/ajh.21176

Source DB: PubMed Journal: Am J Hematol ISSN： 0361-8609 Impact factor: 10.047

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