BACKGROUND: The purpose of the current study was to determine the maximum tolerated dose, dose-limiting toxicities, pharmacokinetic profile, and recommended Phase II dose of oral administration of TAS-102, a novel nucleoside formed by the combination of alpha,alpha,alpha-trifluorothymidine (FTD) and a thymidine phosphorylase inhibitor (TPI: 5-chloro-6-(2-iminopyrrolidin-1-yl)methyl-2,4(1H,3H)-pyrimidinedione). METHODS: Eligible patients had advanced solid tumors, adequate organ function, and had not received anticancer therapy in the preceding 4 weeks. TAS-102 was administered orally once daily for 14 days, followed by a 1-week rest, repeated every 3 weeks. The initial dose of TAS-102 administered was 100 mg/m2/day. The first 2 patients treated at that dose experienced substantial toxicity and, therefore, lower dose levels of TAS-102 were subsequently explored. RESULTS: Fourteen patients were enrolled; all patients were evaluable for toxicity assessment and 12 were evaluable for response. The initial dose explored was 100 mg/m2/day, based on a preclinical monkey model. However, the first 2 patients experienced bone marrow suppression of Grade 3 or 4 in course 1. The protocol was amended to study the next cohort of patients at 50 mg/m2/day. At this dose level no Grade 3 or 4 toxicities were observed in course 1. In the subsequent dose level (60 mg/m2/day), 3 of 6 patients experienced Grade 3 or 4 granulocytopenia as dose-limiting toxicity. Three additional patients for a total of 6 were enrolled at 50 mg/m2/day without occurrence of dose-limiting toxicity. Thus, 50 mg/m2/day was declared the maximum tolerated dose for this schedule. CONCLUSIONS: The authors' study showed that 50 mg/m2/day was a tolerable dose of the novel antimetabolite FTD in combination with an inhibitor of its inactivating enzyme TP, and this is the recommended Phase II dose. Evaluation of this daily dose in malignancies for which fluoropyrimidines have failed is needed. (c) 2006 American Cancer Society.
BACKGROUND: The purpose of the current study was to determine the maximum tolerated dose, dose-limiting toxicities, pharmacokinetic profile, and recommended Phase II dose of oral administration of TAS-102, a novel nucleoside formed by the combination of alpha,alpha,alpha-trifluorothymidine (FTD) and a thymidine phosphorylase inhibitor (TPI: 5-chloro-6-(2-iminopyrrolidin-1-yl)methyl-2,4(1H,3H)-pyrimidinedione). METHODS: Eligible patients had advanced solid tumors, adequate organ function, and had not received anticancer therapy in the preceding 4 weeks. TAS-102 was administered orally once daily for 14 days, followed by a 1-week rest, repeated every 3 weeks. The initial dose of TAS-102 administered was 100 mg/m2/day. The first 2 patients treated at that dose experienced substantial toxicity and, therefore, lower dose levels of TAS-102 were subsequently explored. RESULTS: Fourteen patients were enrolled; all patients were evaluable for toxicity assessment and 12 were evaluable for response. The initial dose explored was 100 mg/m2/day, based on a preclinical monkey model. However, the first 2 patients experienced bone marrow suppression of Grade 3 or 4 in course 1. The protocol was amended to study the next cohort of patients at 50 mg/m2/day. At this dose level no Grade 3 or 4 toxicities were observed in course 1. In the subsequent dose level (60 mg/m2/day), 3 of 6 patients experienced Grade 3 or 4 granulocytopenia as dose-limiting toxicity. Three additional patients for a total of 6 were enrolled at 50 mg/m2/day without occurrence of dose-limiting toxicity. Thus, 50 mg/m2/day was declared the maximum tolerated dose for this schedule. CONCLUSIONS: The authors' study showed that 50 mg/m2/day was a tolerable dose of the novel antimetabolite FTD in combination with an inhibitor of its inactivating enzyme TP, and this is the recommended Phase II dose. Evaluation of this daily dose in malignancies for which fluoropyrimidines have failed is needed. (c) 2006 American Cancer Society.
Authors: James J Lee; Jabed Seraj; Kenichiro Yoshida; Hirokazu Mizuguchi; Sandra Strychor; Jillian Fiejdasz; Tyeler Faulkner; Robert A Parise; Patrick Fawcett; Laura Pollice; Scott Mason; Jeremy Hague; Marie Croft; James Nugteren; Charles Tedder; Weijing Sun; Edward Chu; Jan Hendrik Beumer Journal: Cancer Chemother Pharmacol Date: 2016-01-19 Impact factor: 3.333
Authors: Muhammad Wasif Saif; Lee Rosen; Michelle A Rudek; Weijing Sun; Dale R Shepard; Carlos Becerra; Fumiaki Yamashita; Paul Bebeau; Robert Winkler Journal: Br J Clin Pharmacol Date: 2019-03-28 Impact factor: 4.335
Authors: A Fernandez Montes; F Vazquez Rivera; N Martinez Lago; M Covela Rúa; A Cousillas Castiñeiras; P Gonzalez Villarroel; J de la Cámara Gómez; J C Méndez Méndez; M Salgado Fernández; S Candamio Folgar; M Reboredo López; M Carmona Campos; E Gallardo Martín; M Jorge Fernández; M L Pellón Augusto; L París Bouzas; J García Gómez Journal: Clin Transl Oncol Date: 2019-05-09 Impact factor: 3.405
Authors: Michael J Overman; Gauri Varadhachary; Scott Kopetz; Melanie B Thomas; Masakazu Fukushima; Keizo Kuwata; Akira Mita; Robert A Wolff; Paulo M Hoff; Henry Xiong; James L Abbruzzese Journal: Invest New Drugs Date: 2008-06-05 Impact factor: 3.850
Authors: Sakti Chakrabarti; Tyler J Zemla; Daniel H Ahn; Fang-Shu Ou; Briant Fruth; Mitesh J Borad; Mindy L Hartgers; Jaclynn Wessling; Rachel L Walkes; Steven R Alberts; Robert R McWilliams; Minetta C Liu; Lori M Durgin; Tanios S Bekaii-Saab; Amit Mahipal Journal: Oncologist Date: 2019-12-11