Literature DB >> 16902751

Compartmentalized cAMP/PKA signalling regulates cardiac excitation-contraction coupling.

Valentina Lissandron1, Manuela Zaccolo.   

Abstract

The sympathetic control over excitation-contraction coupling (ECC) is mediated by the cAMP/PKA signalling pathway. However, in the myocyte, the same signalling pathway is responsible for triggering a plethora of diverse intracellular functions the control of which must be independent of the regulation of ECC. Here we discuss what are the molecular mechanisms leading to selective modulation of ECC in cardiac myocytes with a particular focus on the role of spatial confinement of PKA subsets and the compartmentalization of cAMP.

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Year:  2006        PMID： 16902751     DOI： 10.1007/s10974-006-9077-2

Source DB:  PubMed          Journal:  J Muscle Res Cell Motil        ISSN： 0142-4319            Impact factor:   2.698


  48 in total

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