Literature DB >> 16901694

Synthesis and activity of a folate peptide camptothecin prodrug.

Walter A Henne1, Derek D Doorneweerd, Andrew R Hilgenbrink, Sumith A Kularatne, Philip S Low.   

Abstract

A folate receptor targeted camptothecin prodrug was synthesized using a hydrophilic peptide spacer linked to folate via a releasable disulfide carbonate linker. The conjugate was found to possess high affinity for folate receptor-expressing cells and inhibited cell proliferation in human KB cells with an IC(50) of 10nM. Activity of the prodrug was completely blocked by excess folic acid, demonstrating receptor-mediated uptake.

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Year:  2006        PMID： 16901694     DOI： 10.1016/j.bmcl.2006.07.076

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  28 in total

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2.  Chain-shattering polymeric therapeutics with on-demand drug-release capability.

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Journal:  J Am Chem Soc       Date:  2011-09-09       Impact factor: 15.419

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Authors:  Ajay Kumar; Antonio E Alegria
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Journal:  Adv Drug Deliv Rev       Date:  2011-02-17       Impact factor: 15.470

6.  Dual Targeting of Intracellular Pathogenic Bacteria with a Cleavable Conjugate of Kanamycin and an Antibacterial Cell-Penetrating Peptide.

Authors:  Anna Brezden; Mohamed F Mohamed; Manish Nepal; John S Harwood; Jerrin Kuriakose; Mohamed N Seleem; Jean Chmielewski
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Review 7.  Recent trends in targeted anticancer prodrug and conjugate design.

Authors:  Yashveer Singh; Matthew Palombo; Patrick J Sinko
Journal:  Curr Med Chem       Date:  2008       Impact factor: 4.530

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Authors:  Yevgeny Brudno; Matthew J Pezone; Tracy K Snyder; Oktay Uzun; Christopher T Moody; Michael Aizenberg; David J Mooney
Journal:  Biomaterials       Date:  2018-05-06       Impact factor: 12.479

Review 9.  Co-opting biology to deliver drugs.

Authors:  Parisa Yousefpour; Ashutosh Chilkoti
Journal:  Biotechnol Bioeng       Date:  2014-07-21       Impact factor: 4.530

10.  Brain Delivery of Drug and MRI Contrast Agent: Detection and Quantitative Determination of Brain Deposition of CPT-Glu Using LC-MS/MS and Gd-DTPA Using Magnetic Resonance Imaging.

Authors:  Kayann Tabanor; Phil Lee; Paul Kiptoo; In-Young Choi; Erica B Sherry; Cheyenne Sun Eagle; Todd D Williams; Teruna J Siahaan
Journal:  Mol Pharm       Date:  2016-01-06       Impact factor: 4.939
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