Literature DB >> 16901642

alpha-synuclein from platelets is not phosphorylated at serine 129 in Parkinson's disease and multiple system atrophy.

Clifford W Shults1, Jennifer M Barrett, Deborah Fontaine.   

Abstract

Parkinson's disease (PD) and multiple system atrophy (MSA) are characterized pathologically by inclusions in the brain containing alpha-synuclein, which is phosphorylated at serine 129. alpha-Synuclein is present not only in the brain but also in platelets; platelets have previously been used to study mitochondrial function in PD. We undertook to determine whether alpha-synuclein extracted from platelets of patients with PD and MSA is phosphorylated at serine 129 and could be used as a peripheral marker of these disorders. Immunoblots indicated that platelet alpha-synuclein is not phosphorylated at serine 129 in PD and MSA.

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Year:  2006        PMID： 16901642     DOI： 10.1016/j.neulet.2006.07.006

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  2 in total

1.  Quantitative PCR-based screening of alpha-synuclein multiplication in multiple system atrophy.

Authors:  Sarah J Lincoln; Owen A Ross; Nicole M Milkovic; Dennis W Dickson; Alex Rajput; Christopher A Robinson; Spiridon Papapetropoulos; Deborah C Mash; Matthew J Farrer
Journal:  Parkinsonism Relat Disord       Date:  2007-02-08       Impact factor: 4.891

2.  Post mortem cerebrospinal fluid α-synuclein levels are raised in multiple system atrophy and distinguish this from the other α-synucleinopathies, Parkinson's disease and Dementia with Lewy bodies.

Authors:  P G Foulds; O Yokota; A Thurston; Y Davidson; Z Ahmed; J Holton; J C Thompson; H Akiyama; T Arai; M Hasegawa; A Gerhard; D Allsop; D M A Mann
Journal:  Neurobiol Dis       Date:  2011-08-10       Impact factor: 5.996
  2 in total

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