| Literature DB >> 16899366 |
Vince S C Yeh1, Jyoti R Patel, Hong Yong, Ravi Kurukulasuriya, Steven Fung, Katina Monzon, William Chiou, Jiahong Wang, Deanne Stolarik, Hovis Imade, David Beno, Michael Brune, Peer Jacobson, Hing Sham, J T Link.
Abstract
A series of metabolically stable adamantane amide 11beta-HSD1 inhibitors have been synthesized and biologically evaluated. These compounds exhibit excellent HSD1 potency and HSD2 selectivity and good pharmacokinetic and pharmacodynamic profiles.Entities:
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Year: 2006 PMID： 16899366 DOI： 10.1016/j.bmcl.2006.07.055
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823