OBJECTIVE: To evaluate whether T cells expressing CCR5 and CXCR3 from multiple sclerosis (MS) patients are more resistant to apoptosis. METHODS: Expression of CD69, TNF-R1, Fas, FasL, bcl-2, and bax was investigated in 41 MS patients and 12 healthy controls by flow cytometry in CD4+ and CD8+ T cells expressing CCR5 and CXCR3. RESULTS: In MS patients, the percentage of CD69 was increased and Fas expression decreased in CD4+ CCR5+ T cells. INTERPRETATION: The lower Fas expression in activated CD4+ CCR5+ T cells might contribute to disease pathogenesis by prolonging cell survival and favoring their migration into the CNS.
OBJECTIVE: To evaluate whether T cells expressing CCR5 and CXCR3 from multiple sclerosis (MS) patients are more resistant to apoptosis. METHODS: Expression of CD69, TNF-R1, Fas, FasL, bcl-2, and bax was investigated in 41 MSpatients and 12 healthy controls by flow cytometry in CD4+ and CD8+ T cells expressing CCR5 and CXCR3. RESULTS: In MSpatients, the percentage of CD69 was increased and Fas expression decreased in CD4+ CCR5+ T cells. INTERPRETATION: The lower Fas expression in activated CD4+ CCR5+ T cells might contribute to disease pathogenesis by prolonging cell survival and favoring their migration into the CNS.
Authors: Chotima Böttcher; Camila Fernández-Zapata; Stephan Schlickeiser; Desiree Kunkel; Axel R Schulz; Henrik E Mei; Carl Weidinger; René M Gieß; Susanna Asseyer; Britta Siegmund; Friedemann Paul; Klemens Ruprecht; Josef Priller Journal: Sci Rep Date: 2019-12-19 Impact factor: 4.379
Authors: Silvia M Tietz; Regina Hofmann; Tobias Thomas; Björn Tackenberg; Matthias Gaestel; Martin Berghoff Journal: PLoS One Date: 2014-06-25 Impact factor: 3.240