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Literature DB >> 19037324

Immunologic pathogenesis of multiple sclerosis.

Abstract

Multiple sclerosis (MS) is an autoimmune disease. The etiology and pathogenesis of MS remain unclear. At present, there are substantial evidences to support the hypothesis that genetics plays a crucial role. The people who have genetic predisposing genes easily develop immune-mediated disorder, probably in conjunction with environmental factors. The aim of this review is to describe recent observations regarding the immunologic pathogenesis of MS.

Entities: Disease Species

Mesh：

Substances：

Year: 2008 PMID： 19037324 PMCID： PMC5552594 DOI： 10.1007/s12264-008-2429-8

Source DB: PubMed Journal: Neurosci Bull ISSN： 1995-8218 Impact factor: 5.203

42 in total

1. Mediators of apoptosis Fas and FasL predict disability progression in multiple sclerosis over a period of 10 years.

Authors: L Lopatinskaya; J Zwemmer; B Uitdehaag; K Lucas; C Polman; L Nagelkerken
Journal: Mult Scler Date: 2006-12 Impact factor: 6.312

2. The demyelinating potential of antibodies to myelin oligodendrocyte glycoprotein is related to their ability to fix complement.

Authors: S J Piddlesden; H Lassmann; F Zimprich; B P Morgan; C Linington
Journal: Am J Pathol Date: 1993-08 Impact factor: 4.307

3. A critical role for IL-4 in regulating disease severity in experimental allergic encephalomyelitis as demonstrated in IL-4-deficient C57BL/6 mice and BALB/c mice.

Authors: M Falcone; A J Rajan; B R Bloom; C F Brosnan
Journal: J Immunol Date: 1998-05-15 Impact factor: 5.422

4. Specificity, magnitude, and kinetics of MOG-specific CD8+ T cell responses during experimental autoimmune encephalomyelitis.

Authors: Mandy L Ford; Brian D Evavold
Journal: Eur J Immunol Date: 2005-01 Impact factor: 5.532

5. Components in multiple sclerosis cerebrospinal fluid that are detected by radioimmunoassay for myelin basic protein.

Authors: J H Carson; E Barbarese; P E Braun; T A McPherson
Journal: Proc Natl Acad Sci U S A Date: 1978-04 Impact factor: 11.205

6. The role of IL-12 in the induction of intravenous tolerance in experimental autoimmune encephalomyelitis.

Authors: Guang-Xian Zhang; Hui Xu; Masahiko Kishi; Divina Calida; Abdolmohamad Rostami
Journal: J Immunol Date: 2002-03-01 Impact factor: 5.422

7. Effective and selective immune surveillance of the brain by MHC class I-restricted cytotoxic T lymphocytes.

Authors: Julie Cabarrocas; Jan Bauer; Eliane Piaggio; Roland Liblau; Hans Lassmann
Journal: Eur J Immunol Date: 2003-05 Impact factor: 5.532

8. IL-5-deficient mice are susceptible to experimental autoimmune encephalomyelitis.

Authors: Catherine Weir; Claude C A Bernard; B Thomas Bäckström
Journal: Int Immunol Date: 2003-11 Impact factor: 4.823

Review 9. Specific antigen vaccination to treat autoimmune disease.

Authors: Hugh McDevitt
Journal: Proc Natl Acad Sci U S A Date: 2004-10-04 Impact factor: 11.205

10. T helper cell type 1 (Th1), Th2 and Th17 responses to myelin basic protein and disease activity in multiple sclerosis.

Authors: Chris J Hedegaard; Martin Krakauer; Klaus Bendtzen; Henrik Lund; Finn Sellebjerg; Claus H Nielsen
Journal: Immunology Date: 2008-04-04 Impact factor: 7.397

6 in total

Immunologic pathogenesis of multiple sclerosis.

1. Mediators of apoptosis Fas and FasL predict disability progression in multiple sclerosis over a period of 10 years.

2. The demyelinating potential of antibodies to myelin oligodendrocyte glycoprotein is related to their ability to fix complement.

3. A critical role for IL-4 in regulating disease severity in experimental allergic encephalomyelitis as demonstrated in IL-4-deficient C57BL/6 mice and BALB/c mice.

4. Specificity, magnitude, and kinetics of MOG-specific CD8+ T cell responses during experimental autoimmune encephalomyelitis.

5. Components in multiple sclerosis cerebrospinal fluid that are detected by radioimmunoassay for myelin basic protein.

6. The role of IL-12 in the induction of intravenous tolerance in experimental autoimmune encephalomyelitis.

7. Effective and selective immune surveillance of the brain by MHC class I-restricted cytotoxic T lymphocytes.

8. IL-5-deficient mice are susceptible to experimental autoimmune encephalomyelitis.

Review 9. Specific antigen vaccination to treat autoimmune disease.

10. T helper cell type 1 (Th1), Th2 and Th17 responses to myelin basic protein and disease activity in multiple sclerosis.

1. CSF Brain-Reactive Autoantibodies are Elevated in Patients with Viral Encephalitis.

Review 2. Multiple Sclerosis: Therapeutic Strategies on the Horizon.

Review 3. Polarization of macrophages and microglia in inflammatory demyelination.

Review 4. Review of the diagnosis and clinical features of multiple sclerosis in China.

Review 5. Pregnancy-Related Immune Changes and Demyelinating Diseases of the Central Nervous System.

6. Can vitamin d suppress endothelial cells apoptosis in multiple sclerosis patients?