| Literature DB >> 16898790 |
Matthew P Bourbeau1, James T Rider.
Abstract
[reaction: see text] A series of 4-alkyl-5-aminoisoxazoles have been synthesized in high yield by nucleophilic addition of lithiated alkyl nitriles to (alpha)-chlorooximes. The scope and limitations of this reaction were examined by varying the nature of the nitrile and chloride oxime.Entities:
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Year: 2006 PMID： 16898790 DOI： 10.1021/ol061260+
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005