Literature DB >> 16898789

A convenient and genuine equivalent to HZrCp2Cl generated in situ from ZrCp2Cl2-DIBAL-H.

Zhihong Huang1, Ei-ichi Negishi.   

Abstract

[reaction: see text] Slow addition of 1 equiv of (i)Bu2AlH to ZrCp2Cl2 in THF provides a convenient route to either HZrCp2Cl-(i)Bu2AlCl (Reagent I) or HZrCp2Cl (Reagents II and III). The latter represents a highly convenient route to genuine HZrCp2Cl, while Reagent I is useful for regio- and stereoselective conversion of 1- and 2-alkynes into (E)-1-iodo-1-alkenes and (E)-2-iodo-2-alkenes, respectively.

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Year:  2006        PMID： 16898789     DOI： 10.1021/ol061202o

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  30 in total

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