Literature DB >> 16897192

Longevity-associated NADH dehydrogenase subunit-2 237 Leu/Met polymorphism influences the effects of alcohol consumption on serum uric acid levels in nonobese Japanese men.

Akatsuki Kokaze1, Mamoru Ishikawa2,3, Naomi Matsunaga2, Masao Yoshida2, Masao Satoh4, Koji Teruya5, Rie Honmyo2, Misako Yorimitsu2, Yumi Masuda2, Yoshiko Uchida2, Yutaka Takashima2.   

Abstract

NADH dehydrogenase subunit-2 237 leucine/methionine (ND2-237 Leu/Met) polymorphism is reportedly associated with longevity in the Japanese population. The ND2-237Met genotype may confer resistance to cardiovascular and cerebrovascular atherogenic diseases. Hyperuricemia is one of the risk factors for cardiovascular disease. To investigate whether ND2-237 Leu/Met polymorphism is associated with serum uric acid (SUA) levels, we conducted a cross-sectional study in 321 healthy Japanese male subjects. In nonobese (body mass index, BMI<25) male subjects, interaction between ND2-237 Leu/Met genotypes and drinking frequency on SUA levels was observed (P=0.031). The SUA levels were significantly higher in daily drinkers with ND2-237Leu than in non-daily drinkers with ND2-237Leu (P=0.018). In nonobese men, after adjustment for covariates, daily drinkers with ND2-237Leu had a significantly higher odds ratio (OR) for hyperuricemia (SUA> or =6.5 mg/dl: vs. daily drinkers with ND2-237Met, OR=3.26, 95% confidence interval (CI) 1.14-9.29; vs. non-daily drinkers with ND2-237Leu, OR=3.22, 95% CI 1.39-7.45; SUA> or =7.0 mg/dl: vs. non-daily drinkers with ND2-237Met, OR=3.53, 95% CI 1.00-12.4). However, in obese (BMI> or =25) men, no significant interaction between ND2-237 Leu/Met polymorphism and habitual drinking on SUA levels or on the risk for hyperuricemia was observed. These results suggest that ND2-237 Leu/Met polymorphism modulates the effects of daily alcohol consumption on SUA levels in nonobese Japanese men.

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Year:  2006        PMID： 16897192     DOI： 10.1007/s10038-006-0018-0

Source DB:  PubMed          Journal:  J Hum Genet        ISSN： 1434-5161            Impact factor:   3.172


  30 in total

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3.  Behavioural and biological correlates of serum uric acid: a study of self-defence officials in Japan.

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5.  Association of the mitochondrial DNA 5178 A/C polymorphism with serum lipid levels in the Japanese population.

Authors:  A Kokaze; M Ishikawa; N Matsunaga; M Yoshida; Y Sekine; K Teruya; N Takeda; Y Sumiya; Y Uchida; Y Takashima
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7.  Cerebrovascular disorders and genetic polymorphisms: mitochondrial DNA5178C is predominant in cerebrovascular disorders.

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9.  Longevity-associated mitochondrial DNA 5178 A/C polymorphism and blood pressure in the Japanese population.

Authors:  A Kokaze; M Ishikawa; N Matsunaga; M Yoshida; Y Sekine; K Sekiguchi; M Harada; M Satoh; K Teruya; N Takeda; S Fukazawa; Y Uchida; Y Takashima
Journal:  J Hum Hypertens       Date:  2004-01       Impact factor: 3.012

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  7 in total

1.  Longevity-associated mitochondrial DNA 5178 C/A polymorphism and its interaction with cigarette consumption are associated with pulmonary function in middle-aged Japanese men.

Authors:  Akatsuki Kokaze; Mamoru Ishikawa; Naomi Matsunaga; Masao Yoshida; Masao Satoh; Koji Teruya; Rie Honmyo; Takako Shirasawa; Hiromi Hoshino; Yutaka Takashima
Journal:  J Hum Genet       Date:  2007-07-17       Impact factor: 3.172

2.  Joint effect of longevity-associated mitochondrial DNA 5178 C/A polymorphism and alcohol consumption on risk of hyper-LDL cholesterolemia in middle-aged Japanese men.

Authors:  Teruyoshi Kawamoto; Akatsuki Kokaze; Mamoru Ishikawa; Naomi Matsunaga; Kanae Karita; Masao Yoshida; Naoki Shimada; Tadahiro Ohtsu; Takako Shirasawa; Hirotaka Ochiai; Taku Ito; Hiromi Hoshino; Yutaka Takashima
Journal:  Lipids Health Dis       Date:  2011-06-25       Impact factor: 3.876

3.  Joint effects of mitochondrial DNA 5178 C/A polymorphism and coffee consumption or alcohol consumption on clustering of cardiovascular risk factors in middle-aged Japanese men: a cross-sectional study.

Authors:  Taku Ito; Akatsuki Kokaze; Mamoru Ishikawa; Naomi Matsunaga; Kanae Karita; Masao Yoshida; Tadahiro Ohtsu; Hirotaka Ochiai; Takako Shirasawa; Hinako Nanri; Hiromi Hoshino; Yutaka Takashima
Journal:  J Diabetes Metab Disord       Date:  2014-01-06

4.  NADH dehydrogenase subunit-2 237 Leu/Met polymorphism modulates the effects of coffee consumption on the risk of hypertension in middle-aged Japanese men.

Authors:  Akatsuki Kokaze; Mamoru Ishikawa; Naomi Matsunaga; Kanae Karita; Masao Yoshida; Tadahiro Ohtsu; Takako Shirasawa; Hideaki Sekii; Taku Ito; Teruyoshi Kawamoto; Yutaka Takashima
Journal:  J Epidemiol       Date:  2009-08-08       Impact factor: 3.211

5.  Interaction between mitochondrial NADH dehydrogenase subunit-2 5178 C > A and clinical risk factors on the susceptibility of essential hypertension in Chinese population.

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6.  Longevity-associated mitochondrial DNA 5178 C/A polymorphism modifies effect of aging on renal function in male Japanese health checkup examinees: an exploratory cross-sectional study.

Authors:  Iichiro Ohtsu; Mamoru Ishikawa; Naomi Matsunaga; Kanae Karita; Masao Yoshida; Hirotaka Ochiai; Takako Shirasawa; Takahiko Yoshimoto; Akira Minoura; Shogo Sai; Akatsuki Kokaze
Journal:  J Physiol Anthropol       Date:  2019-09-05       Impact factor: 2.867

7.  Combined effect of mitochondrial DNA 5178 C/A polymorphism and alcohol consumption on estimated glomerular filtration rate in male Japanese health check-up examinees: a cross-sectional study.

Authors:  Akatsuki Kokaze; Mamoru Ishikawa; Naomi Matsunaga; Kanae Karita; Masao Yoshida; Naoki Shimada; Tadahiro Ohtsu; Takako Shirasawa; Hirotaka Ochiai; Hiromi Hoshino; Yutaka Takashima
Journal:  BMC Nephrol       Date:  2013-02-12       Impact factor: 2.388
  7 in total

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