| Literature DB >> 12039661 |
Ryuichi Ohkubo1, Masanori Nakagawa, Ken-ichi Ikeda, Tomoko Kodama, Kimiyoshi Arimura, Suminori Akiba, Minoru Saito, Yosuke Ookatsu, Yoshihiko Atsuchi, Yoshihisa Yamano, Mitsuhiro Osame.
Abstract
We studied polymorphisms of mitochondrial DNA 5178cytosine/adenine (mt5178C/A) and angiotensin I-converting enzyme (ACE) genes (DCP1) in 127 cerebrovascular disorder (CVD) patients and 294 age-matched normal controls to clarify the genetic background of Japanese patients with CVD. Mt5178C was predominant in CVD patients compared with controls (P<0.01). The frequency of DCP1 insertion (I) and deletion (D) alleles showed no significant difference between the CVD patients and controls or between each CVD subgroup. Although the number of CVD patients in the present study was too small to make a final conclusion, mt5178C might be one of the genetic factors to be considered in Japanese patients with CVD.Entities:
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Year: 2002 PMID： 12039661 DOI： 10.1016/s0022-510x(02)00055-2
Source DB: PubMed Journal: J Neurol Sci ISSN： 0022-510X Impact factor: 3.181