Literature DB >> 1689585

Calcium antagonists inhibit met-enkephalin immunoreactive material release: in vitro and ex vivo experiments.

S Govoni1, I Goss, S Di Giovine, F Battaini, M Trabucchi.   

Abstract

Depolarizing stimuli increase the release of neurotransmitter met-enkephalin from rat striatal slices. Bay K8644, a calcium agonist, significantly enhances the submaximal release of this peptide. Several organic calcium antagonists, including nimodipine, nifedipine, nicardipine, gallopamil and flunarizine, are able to inhibit the potassium-evoked met-enkephalin release both in vitro and ex vivo. The data suggest that the release of this neuropeptide is modulated by calcium antagonist-sensitive calcium channels.

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Year:  1990        PMID： 1689585     DOI： 10.1007/bf01245019

Source DB:  PubMed          Journal:  J Neural Transm Gen Sect


  22 in total

Review 1.  Ca2+ channel ligands: structure-function relationships of the 1,4-dihydropyridines.

Authors:  D J Triggle; D A Langs; R A Janis
Journal:  Med Res Rev       Date:  1989 Apr-Jun       Impact factor: 12.944

2.  Three types of neuronal calcium channel with different calcium agonist sensitivity.

Authors:  M C Nowycky; A P Fox; R W Tsien
Journal:  Nature       Date:  1985 Aug 1-7       Impact factor: 49.962

3.  Bay K 8644 stimulation of calcium entry and endogenous dopamine release in rat striatal synaptosomes antagonized by nimodipine.

Authors:  J J Woodward; S W Leslie
Journal:  Brain Res       Date:  1986-04-09       Impact factor: 3.252

4.  Interaction of iodinated enkephalin analogues with opiate receptors.

Authors:  R J Miller; K J Chang; J Leighton; P Cuatrecasas
Journal:  Life Sci       Date:  1978-02       Impact factor: 5.037

5.  The effects of calcium channel agonists and antagonists on the release of endogenous glutamate from cerebellar slices.

Authors:  S Barnes; J A Davies
Journal:  Neurosci Lett       Date:  1988-09-23       Impact factor: 3.046

Review 6.  Peptidergic neurones.

Authors:  T Hökfelt; O Johansson; A Ljungdahl; J M Lundberg; M Schultzberg
Journal:  Nature       Date:  1980-04-10       Impact factor: 49.962

7.  The effects of some organic "calcium antagonists" on calcium influx in presynaptic nerve terminals.

Authors:  D A Nachshen; M P Blaustein
Journal:  Mol Pharmacol       Date:  1979-09       Impact factor: 4.436

8.  Dopamine enhances Met-enkephalin efflux from rat striatal slices.

Authors:  G Pasinetti; S Govoni; S di Giovine; P F Spano; M Trabucchi
Journal:  Brain Res       Date:  1984-02-20       Impact factor: 3.252

9.  Neurotensin effect on dopamine release and calcium transport in rat striatum: interactions with diphenylalkylamine calcium antagonists.

Authors:  F Battaini; S Govoni; S Di Giovine; M Trabucchi
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1986-03       Impact factor: 3.000

10.  Neurochemical characteristics of a novel dorsal root ganglion X neuroblastoma hybrid cell line, F-11.

Authors:  P C Francel; K Harris; M Smith; M C Fishman; G Dawson; R J Miller
Journal:  J Neurochem       Date:  1987-05       Impact factor: 5.372
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