Literature DB >> 16895336

Probing enzyme phosphoester interactions by combining mutagenesis and chemical modification of phosphate ester oxygens.

James T Stivers1, Rajesh Nagarajan.   

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Year:  2006        PMID： 16895336      PMCID： PMC2729714          DOI： 10.1021/cr050317n

Source DB:  PubMed          Journal:  Chem Rev        ISSN： 0009-2665            Impact factor:   60.622


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  113 in total

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Review 5.  Protein tyrosine phosphatases and signalling.

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7.  Hydrogen bonding in enzymatic catalysis: analysis of energetic contributions.

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8.  Mechanistic plasticity of DNA topoisomerase IB: phosphate electrostatics dictate the need for a catalytic arginine.

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9.  Structural flexibility in human topoisomerase I revealed in multiple non-isomorphous crystal structures.

Authors:  M R Redinbo; L Stewart; J J Champoux; W G Hol
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10.  Recognition of an unnatural difluorophenyl nucleotide by uracil DNA glycosylase.

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5.  The effects of sulfur substitution for the nucleophile and bridging oxygen atoms in reactions of hydroxyalkyl phosphate esters.

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6.  Uracil DNA glycosylase: revisiting substrate-assisted catalysis by DNA phosphate anions.

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7.  Transition State Charge Stabilization and Acid-Base Catalysis of mRNA Cleavage by the Endoribonuclease RelE.

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8.  Improved Performance of Anti-miRNA Oligonucleotides Using a Novel Non-Nucleotide Modifier.

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10.  Antiplatelet activity, P2Y₁ and P2Y₁₂ inhibition, and metabolism in plasma of stereoisomers of diadenosine 5',5'″-P¹ ,P⁴-dithio-P²,P³-chloromethylenetetraphosphate.

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