Literature DB >> 16893146

Use of proton pump inhibitors during pregnancy and breastfeeding.

Alejandro A Nava-Ocampo1, Elvia Y Velázquez-Armenta, Jung-Yeol Han, Gideon Koren.   

Abstract

QUESTION: A 36-year-old pregnant patient has symptoms of peptic disease. Treatment with diet and lifestyle modifications and also antacids has given her little relief. If she were not pregnant, I would prescribe a proton pump inhibitor (PPI) for her. She is now 4 weeks pregnant, and I need to determine whether PPIs are safe during pregnancy. ANSWER: Data currently available suggest that omeprazole is not teratogenic in humans. While information on other PPIs is limited, a systematic review of the evidence suggests that they are also not teratogenic.

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Year:  2006        PMID： 16893146      PMCID： PMC1781096     

Source DB:  PubMed          Journal:  Can Fam Physician        ISSN： 0008-350X            Impact factor:   3.275


  9 in total

1.  Omeprazole for refractory gastroesophageal reflux disease during pregnancy and lactation.

Authors:  J K Marshall; A B Thompson; D Armstrong
Journal:  Can J Gastroenterol       Date:  1998-04       Impact factor: 3.522

2.  The safety of omeprazole during pregnancy: a multicenter prospective controlled study.

Authors:  A Lalkin; R Loebstein; A Addis; F Ramezani-Namin; P Mastroiacovo; T Mazzone; T Vial; M Bonati; G Koren
Journal:  Am J Obstet Gynecol       Date:  1998-09       Impact factor: 8.661

Review 3.  Review article: the long-term use of proton-pump inhibitors.

Authors:  A S Raghunath; C O'Morain; R C McLoughlin
Journal:  Aliment Pharmacol Ther       Date:  2005-08       Impact factor: 8.171

4.  Use of omeprazole during pregnancy--no hazard demonstrated in 955 infants exposed during pregnancy.

Authors:  B A Källén
Journal:  Eur J Obstet Gynecol Reprod Biol       Date:  2001-05       Impact factor: 2.435

5.  Excretion of pantoprazole in human breast.

Authors:  Lauren Plante; Geraldine M Ferron; Mary Unruh; Philip R Mayer
Journal:  J Reprod Med       Date:  2004-10       Impact factor: 0.142

6.  The safety of proton pump inhibitors in pregnancy: a multicentre prospective controlled study.

Authors:  O Diav-Citrin; J Arnon; S Shechtman; C Schaefer; M R van Tonningen; M Clementi; M De Santis; E Robert-Gnansia; E Valti; H Malm; A Ornoy
Journal:  Aliment Pharmacol Ther       Date:  2005-02-01       Impact factor: 8.171

7.  Use of proton pump inhibitors during pregnancy and rates of major malformations: a meta-analysis.

Authors:  Shekoufeh Nikfar; Mohammad Abdollahi; Myla E Moretti; Laura A Magee; Gideon Koren
Journal:  Dig Dis Sci       Date:  2002-07       Impact factor: 3.199

8.  The outcomes of pregnancy in women exposed to newly marketed drugs in general practice in England.

Authors:  L V Wilton; G L Pearce; R M Martin; F J Mackay; R D Mann
Journal:  Br J Obstet Gynaecol       Date:  1998-08

Review 9.  Gastroesophageal reflux disease during pregnancy.

Authors:  Joel E Richter
Journal:  Gastroenterol Clin North Am       Date:  2003-03       Impact factor: 3.806
  9 in total
  3 in total

1.  Treatment of heartburn and acid reflux associated with nausea and vomiting during pregnancy.

Authors:  Ruth Law; Caroline Maltepe; Pina Bozzo; Adrienne Einarson
Journal:  Can Fam Physician       Date:  2010-02       Impact factor: 3.275

Review 2.  Treating common ear problems in pregnancy: what is safe?

Authors:  Petros V Vlastarakos; Thomas P Nikolopoulos; Leonidas Manolopoulos; Eleftherios Ferekidis; George Kreatsas
Journal:  Eur Arch Otorhinolaryngol       Date:  2007-11-23       Impact factor: 2.503

Review 3.  Treating common problems of the nose and throat in pregnancy: what is safe?

Authors:  Petros V Vlastarakos; Leonidas Manolopoulos; Eleftherios Ferekidis; Aris Antsaklis; Thomas P Nikolopoulos
Journal:  Eur Arch Otorhinolaryngol       Date:  2008-02-12       Impact factor: 2.503
  3 in total

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