B A Källén1. 1. Tornblad Institute, University of Lund, Biskopsgatan 7, S-223 63, Lund, Sweden. embryol@embryol.lu.se
Abstract
OBJECTIVES: To evaluate the magnitude of possible fetal risks involved in maternal use of omeprazole during pregnancy. STUDY DESIGN: Infants whose mothers used omeprazole during pregnancy were identified from the Swedish Medical Birth Registry. A total of 955 exposed infants born in 1995-1999 were identified: 863 of which were exposed in early pregnancy and 131 later in pregnancy and 39 who had been exposed both in early and late pregnancy. Delivery outcome was studied: presence of congenital malformations, perinatal survival, low birth weight, low Apgar score and hospitalization up to the end of 1997. RESULTS: No clear-cut indication of ill effects were seen. Five infants were stillborn and the rate of congenital heart defects was slightly increased, but both effects may be random. CONCLUSIONS: The present dataset and previously published data give no reason for concern after exposure for omeprazole during pregnancy.
OBJECTIVES: To evaluate the magnitude of possible fetal risks involved in maternal use of omeprazole during pregnancy. STUDY DESIGN:Infants whose mothers used omeprazole during pregnancy were identified from the Swedish Medical Birth Registry. A total of 955 exposed infants born in 1995-1999 were identified: 863 of which were exposed in early pregnancy and 131 later in pregnancy and 39 who had been exposed both in early and late pregnancy. Delivery outcome was studied: presence of congenital malformations, perinatal survival, low birth weight, low Apgar score and hospitalization up to the end of 1997. RESULTS: No clear-cut indication of ill effects were seen. Five infants were stillborn and the rate of congenital heart defects was slightly increased, but both effects may be random. CONCLUSIONS: The present dataset and previously published data give no reason for concern after exposure for omeprazole during pregnancy.
Authors: Marlene Anderka; Allen A Mitchell; Carol Louik; Martha M Werler; Sonia Hernández-Diaz; Sonja A Rasmussen Journal: Birth Defects Res A Clin Mol Teratol Date: 2011-11-19