Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Structural analysis of mitochondrial pores.

Literature DB >> 1689251

Structural analysis of mitochondrial pores.

Abstract

Structural information about the channel in the mitochondrial outer membrane, derived from sequence analysis and electron microscopy of two-dimensional crystals, is summarized. A model for the channel is presented, consisting of a cylindrical beta-barrel that is formed by one or two 30-kDa polypeptides, with an alpha-carbon backbone diameter of 3.8 nm. The radial distributions of basic amino acids and lipid-contact regions on the projected cylinder are mapped relative to interchannel bonding sites inferred from channel packing in the arrays. Speculation on the kinds of conformational changes that the channel might undergo is also presented.

Entities: Chemical

Mesh：

Substances：

Year: 1990 PMID： 1689251 DOI： 10.1007/bf02027309

Source DB: PubMed Journal: Experientia ISSN： 0014-4754

46 in total

Review 1. Molecular genetics of the VDAC ion channel: structural model and sequence analysis.

Authors: M Forte; H R Guy; C A Mannella
Journal: J Bioenerg Biomembr Date: 1987-08 Impact factor: 2.945

2. Lateral segregation of sterol and channel proteins in the mitochondrial outer membrane induced by phospholipase A2: evidence from negative-stain electron microscopy using filipin.

Authors: C A Mannella
Journal: J Ultrastruct Mol Struct Res Date: 1988-02

3. Reconstitution in planar lipid bilayers of a voltage-dependent anion-selective channel obtained from paramecium mitochondria.

Authors: S J Schein; M Colombini; A Finkelstein
Journal: J Membr Biol Date: 1976-12-28 Impact factor: 1.843

4. Cytochrome c binds to lipid domains in arrays of mitochondrial outer membrane channels.

Authors: C A Mannella; A J Ribeiro; J Frank
Journal: Biophys J Date: 1987-02 Impact factor: 4.033

5. Hexokinase receptor complex in hepatoma mitochondria: evidence from N,N'-dicyclohexylcarbodiimide-labeling studies for the involvement of the pore-forming protein VDAC.

Authors: R A Nakashima; P S Mangan; M Colombini; P L Pedersen
Journal: Biochemistry Date: 1986-03-11 Impact factor: 3.162

6. Gap junction structures. V. Structural chemistry inferred from X-ray diffraction measurements on sucrose accessibility and trypsin susceptibility.

Authors: L Makowski; D L Caspar; W C Phillips; D A Goodenough
Journal: J Mol Biol Date: 1984-04-15 Impact factor: 5.469

7. Interactions of uranyl ions with lipid bilayer membranes.

Authors: H P Ting-Beall
Journal: J Microsc Date: 1980-02 Impact factor: 1.758

8. Structure of the Channels in the Outer Mitochondrial Membrane: Electron Microscopic Studies of the Periodic Arrays Induced by Phospholipase a(2) Treatment of the Neurospora membrane.

Authors: C A Mannella; A Ribeiro; J Frank
Journal: Biophys J Date: 1986-01 Impact factor: 4.033

9. Molecular cloning and sequencing of cDNA for yeast porin, an outer mitochondrial membrane protein: a search for targeting signal in the primary structure.

Authors: K Mihara; R Sato
Journal: EMBO J Date: 1985-03 Impact factor: 11.598

10. Structure of the outer mitochondrial membrane: ordered arrays of porelike subunits in outer-membrane fractions from Neurospora crassa mitochondria.

Authors: C A Mannella
Journal: J Cell Biol Date: 1982-09 Impact factor: 10.539

14 in total

Review 1. Toward the molecular structure of the mitochondrial channel, VDAC.

Authors: C A Mannella; M Forte; M Colombini
Journal: J Bioenerg Biomembr Date: 1992-02 Impact factor: 2.945

Review 2. The emerging picture of mitochondrial membrane channels.

Authors: C A Mannella; H Tedeschi
Journal: J Bioenerg Biomembr Date: 1992-02 Impact factor: 2.945

3. Classification of projection images of crystalline arrays of the mitochondrial, voltage-dependent anion-selective channel embedded in aurothioglucose.

Authors: X W Guo; C A Mannella
Journal: Biophys J Date: 1992-08 Impact factor: 4.033

Structural analysis of mitochondrial pores.

Review 1. Molecular genetics of the VDAC ion channel: structural model and sequence analysis.

2. Lateral segregation of sterol and channel proteins in the mitochondrial outer membrane induced by phospholipase A2: evidence from negative-stain electron microscopy using filipin.

3. Reconstitution in planar lipid bilayers of a voltage-dependent anion-selective channel obtained from paramecium mitochondria.

4. Cytochrome c binds to lipid domains in arrays of mitochondrial outer membrane channels.

5. Hexokinase receptor complex in hepatoma mitochondria: evidence from N,N'-dicyclohexylcarbodiimide-labeling studies for the involvement of the pore-forming protein VDAC.

6. Gap junction structures. V. Structural chemistry inferred from X-ray diffraction measurements on sucrose accessibility and trypsin susceptibility.

7. Interactions of uranyl ions with lipid bilayer membranes.

8. Structure of the Channels in the Outer Mitochondrial Membrane: Electron Microscopic Studies of the Periodic Arrays Induced by Phospholipase a(2) Treatment of the Neurospora membrane.

9. Molecular cloning and sequencing of cDNA for yeast porin, an outer mitochondrial membrane protein: a search for targeting signal in the primary structure.

10. Structure of the outer mitochondrial membrane: ordered arrays of porelike subunits in outer-membrane fractions from Neurospora crassa mitochondria.

Review 1. Toward the molecular structure of the mitochondrial channel, VDAC.

Review 2. The emerging picture of mitochondrial membrane channels.

3. Classification of projection images of crystalline arrays of the mitochondrial, voltage-dependent anion-selective channel embedded in aurothioglucose.

4. Binding of a synthetic targeting peptide to a mitochondrial channel protein.

5. Conformational change in the mitochondrial channel, VDAC, detected by electron cryo-microscopy.

6. Immunoelectron microscopic study of the distribution of porin on outer membranes of rat heart mitochondria.

7. Molecular dynamics studies of ion permeation in VDAC.

Review 8. Minireview: on the structure and gating mechanism of the mitochondrial channel, VDAC.

Review 9. VDAC structure, selectivity, and dynamics.

Review 10. Transmembrane arrangement of mitochondrial porin or voltage-dependent anion channel (VDAC).