Literature DB >> 16892064

Molecular regulation of H3K4 trimethylation by ASH2L, a shared subunit of MLL complexes.

Melissa M Steward1, Jung-Shin Lee, Aisling O'Donovan, Matt Wyatt, Bradley E Bernstein, Ali Shilatifard.   

Abstract

MLL complexes are homologs of yeast COMPASS capable of methylating histone H3 Lys4 (H3K4). ASH2L, RbBP5 and WDR5 are conserved subunits of MLL complexes with homology to the Cps40/Cps60, Cps50 and Cps30 subunits of COMPASS, respectively. We report that ASH2L differentially regulates MLL's catalysis of H3K4 trimethylation similarly to Cps40 and Cps60. Furthermore, WDR5 is required to maintain MLL complex integrity, including the stability of ASH2L within the complex. These findings offer insight into the molecular role of ASH2L, and by extension that of WDR5, in proper H3K4 trimethylation.

Entities:  

Mesh：

Substances：

Year:  2006        PMID： 16892064     DOI： 10.1038/nsmb1131

Source DB:  PubMed          Journal:  Nat Struct Mol Biol        ISSN： 1545-9985            Impact factor:   15.369


  169 in total

1.  Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.

Authors:  Venkatasubramanian Dharmarajan; Jeong-Heon Lee; Anamika Patel; David G Skalnik; Michael S Cosgrove
Journal:  J Biol Chem       Date:  2012-06-03       Impact factor: 5.157

2.  Charge-based interaction conserved within histone H3 lysine 4 (H3K4) methyltransferase complexes is needed for protein stability, histone methylation, and gene expression.

Authors:  Douglas P Mersman; Hai-Ning Du; Ian M Fingerman; Paul F South; Scott D Briggs
Journal:  J Biol Chem       Date:  2011-12-06       Impact factor: 5.157

3.  Structure of the SPRY domain of human Ash2L and its interactions with RbBP5 and DPY30.

Authors:  Yong Chen; Fang Cao; Bingbing Wan; Yali Dou; Ming Lei
Journal:  Cell Res       Date:  2012-01-10       Impact factor: 25.617

4.  Histone H3R17me2a mark recruits human RNA polymerase-associated factor 1 complex to activate transcription.

Authors:  Jiacai Wu; Wei Xu
Journal:  Proc Natl Acad Sci U S A       Date:  2012-03-26       Impact factor: 11.205

5.  Genome-scale study of transcription factor expression in the branching mouse lung.

Authors:  John C Herriges; Lan Yi; Elizabeth A Hines; Julie F Harvey; Guoliang Xu; Paul A Gray; Qiufu Ma; Xin Sun
Journal:  Dev Dyn       Date:  2012-07-20       Impact factor: 3.780

6.  Licensed to elongate: a molecular mechanism for MLL-based leukaemogenesis.

Authors:  Man Mohan; Chengqi Lin; Erin Guest; Ali Shilatifard
Journal:  Nat Rev Cancer       Date:  2010-09-16       Impact factor: 60.716

Review 7.  Proteomic investigation of epigenetics in neuropsychiatric disorders: a missing link between genetics and behavior?

Authors:  Mariana D Plazas-Mayorca; Kent E Vrana
Journal:  J Proteome Res       Date:  2010-09-09       Impact factor: 4.466

Review 8.  Role of histone methylation and demethylation in adipogenesis and obesity.

Authors:  Masashi Okamura; Takeshi Inagaki; Toshiya Tanaka; Juro Sakai
Journal:  Organogenesis       Date:  2010 Jan-Mar       Impact factor: 2.500

9.  Trimethylation of histone H3 lysine 4 impairs methylation of histone H3 lysine 9: regulation of lysine methyltransferases by physical interaction with their substrates.

Authors:  Olivier Binda; Gary LeRoy; Dennis J Bua; Benjamin A Garcia; Or Gozani; Stéphane Richard
Journal:  Epigenetics       Date:  2010 Nov-Dec       Impact factor: 4.528

10.  H3K4 methyltransferase Set1 is involved in maintenance of ergosterol homeostasis and resistance to Brefeldin A.

Authors:  Paul F South; Kayla M Harmeyer; Nina D Serratore; Scott D Briggs
Journal:  Proc Natl Acad Sci U S A       Date:  2013-02-04       Impact factor: 11.205
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.