Literature DB >> 20592862

Role of histone methylation and demethylation in adipogenesis and obesity.

Masashi Okamura1, Takeshi Inagaki, Toshiya Tanaka, Juro Sakai.   

Abstract

Adipocyte differentiation is a complex developmental process that involves the coordinated interplay of numerous transcription factors. PPARγ has emerged as a master regulator of adipogenesis and recent global target gene analysis demonstrated that PPARγ targets many genes encoding chromatin modification enzymes as well as genes of lipid metabolism and storage. Among such modification enzymes are histone lysine methyltransferases, which play important roles in transcriptional regulation. Histone methyltransferases are involved in PPARγ gene expression and subsequent adipogenesis. In addition, recent studies revealed that demethylation of histone H3 at lys9 is associated with resistance to obesity. We here review the role of histone methylation and demethylation in adipogenesis, metabolism and obesity.

Entities:  

Keywords:  PR-Set7; Setd8; Setdb1; Wnt; adipogenesis; epigenetics; histone lysine methyltransferase (HKMT); metabolic syndrome; obesity; peroxisome proliferator-activated receptor (PPAR)

Mesh：

Substances：

Year:  2010        PMID： 20592862      PMCID： PMC2861740          DOI： 10.4161/org.6.1.11121

Source DB:  PubMed          Journal:  Organogenesis        ISSN： 1547-6278            Impact factor:   2.500


  80 in total

1.  UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development.

Authors:  Karl Agger; Paul A C Cloos; Jesper Christensen; Diego Pasini; Simon Rose; Juri Rappsilber; Irina Issaeva; Eli Canaani; Anna Elisabetta Salcini; Kristian Helin
Journal:  Nature       Date:  2007-08-22       Impact factor: 49.962

2.  A histone H3 lysine 27 demethylase regulates animal posterior development.

Authors:  Fei Lan; Peter E Bayliss; John L Rinn; Johnathan R Whetstine; Jordon K Wang; Shuzhen Chen; Shigeki Iwase; Roman Alpatov; Irina Issaeva; Eli Canaani; Thomas M Roberts; Howard Y Chang; Yang Shi
Journal:  Nature       Date:  2007-09-12       Impact factor: 49.962

3.  Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination.

Authors:  Min Gyu Lee; Raffaella Villa; Patrick Trojer; Jessica Norman; Kai-Ping Yan; Danny Reinberg; Luciano Di Croce; Ramin Shiekhattar
Journal:  Science       Date:  2007-08-30       Impact factor: 47.728

4.  A histone lysine methyltransferase activated by non-canonical Wnt signalling suppresses PPAR-gamma transactivation.

Authors:  Ichiro Takada; Masatomo Mihara; Miyuki Suzawa; Fumiaki Ohtake; Shinji Kobayashi; Mamoru Igarashi; Min-Young Youn; Ken-ichi Takeyama; Takashi Nakamura; Yoshihiro Mezaki; Shinichiro Takezawa; Yoshiko Yogiashi; Hirochika Kitagawa; Gen Yamada; Shinji Takada; Yasuhiro Minami; Hiroshi Shibuya; Kunihiro Matsumoto; Shigeaki Kato
Journal:  Nat Cell Biol       Date:  2007-10-21       Impact factor: 28.824

5.  Identification of JmjC domain-containing UTX and JMJD3 as histone H3 lysine 27 demethylases.

Authors:  Sunhwa Hong; Young-Wook Cho; Li-Rong Yu; Hong Yu; Timothy D Veenstra; Kai Ge
Journal:  Proc Natl Acad Sci U S A       Date:  2007-11-14       Impact factor: 11.205

6.  Histone demethylase JHDM2A is critical for Tnp1 and Prm1 transcription and spermatogenesis.

Authors:  Yuki Okada; Greg Scott; Manas K Ray; Yuji Mishina; Yi Zhang
Journal:  Nature       Date:  2007-10-17       Impact factor: 49.962

7.  Transcriptional regulation of adipogenesis by KLF4.

Authors:  Kivanç Birsoy; Zhu Chen; Jeffrey Friedman
Journal:  Cell Metab       Date:  2008-04       Impact factor: 27.287

8.  The orphan nuclear receptor chicken ovalbumin upstream promoter-transcription factor II is a critical regulator of adipogenesis.

Authors:  Zhao Xu; Songtao Yu; Chung-Hsin Hsu; Jun Eguchi; Evan D Rosen
Journal:  Proc Natl Acad Sci U S A       Date:  2008-02-04       Impact factor: 11.205

9.  Genome-wide maps of chromatin state in pluripotent and lineage-committed cells.

Authors:  Tarjei S Mikkelsen; Manching Ku; David B Jaffe; Biju Issac; Erez Lieberman; Georgia Giannoukos; Pablo Alvarez; William Brockman; Tae-Kyung Kim; Richard P Koche; William Lee; Eric Mendenhall; Aisling O'Donovan; Aviva Presser; Carsten Russ; Xiaohui Xie; Alexander Meissner; Marius Wernig; Rudolf Jaenisch; Chad Nusbaum; Eric S Lander; Bradley E Bernstein
Journal:  Nature       Date:  2007-07-01       Impact factor: 49.962

10.  Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.

Authors:  Eleftheria Zeggini; Laura J Scott; Richa Saxena; Benjamin F Voight; Jonathan L Marchini; Tianle Hu; Paul I W de Bakker; Gonçalo R Abecasis; Peter Almgren; Gitte Andersen; Kristin Ardlie; Kristina Bengtsson Boström; Richard N Bergman; Lori L Bonnycastle; Knut Borch-Johnsen; Noël P Burtt; Hong Chen; Peter S Chines; Mark J Daly; Parimal Deodhar; Chia-Jen Ding; Alex S F Doney; William L Duren; Katherine S Elliott; Michael R Erdos; Timothy M Frayling; Rachel M Freathy; Lauren Gianniny; Harald Grallert; Niels Grarup; Christopher J Groves; Candace Guiducci; Torben Hansen; Christian Herder; Graham A Hitman; Thomas E Hughes; Bo Isomaa; Anne U Jackson; Torben Jørgensen; Augustine Kong; Kari Kubalanza; Finny G Kuruvilla; Johanna Kuusisto; Claudia Langenberg; Hana Lango; Torsten Lauritzen; Yun Li; Cecilia M Lindgren; Valeriya Lyssenko; Amanda F Marvelle; Christa Meisinger; Kristian Midthjell; Karen L Mohlke; Mario A Morken; Andrew D Morris; Narisu Narisu; Peter Nilsson; Katharine R Owen; Colin N A Palmer; Felicity Payne; John R B Perry; Elin Pettersen; Carl Platou; Inga Prokopenko; Lu Qi; Li Qin; Nigel W Rayner; Matthew Rees; Jeffrey J Roix; Anelli Sandbaek; Beverley Shields; Marketa Sjögren; Valgerdur Steinthorsdottir; Heather M Stringham; Amy J Swift; Gudmar Thorleifsson; Unnur Thorsteinsdottir; Nicholas J Timpson; Tiinamaija Tuomi; Jaakko Tuomilehto; Mark Walker; Richard M Watanabe; Michael N Weedon; Cristen J Willer; Thomas Illig; Kristian Hveem; Frank B Hu; Markku Laakso; Kari Stefansson; Oluf Pedersen; Nicholas J Wareham; Inês Barroso; Andrew T Hattersley; Francis S Collins; Leif Groop; Mark I McCarthy; Michael Boehnke; David Altshuler
Journal:  Nat Genet       Date:  2008-03-30       Impact factor: 38.330
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  36 in total

1.  Poly(ADP-ribose)polymerase-1 (PARP1) controls adipogenic gene expression and adipocyte function.

Authors:  Süheda Erener; Mareike Hesse; Radina Kostadinova; Michael O Hottiger
Journal:  Mol Endocrinol       Date:  2011-11-03

2.  Epigenetics lights up the obesity field.

Authors:  Amelia Marti; Jose Ordovas
Journal:  Obes Facts       Date:  2011-06-17       Impact factor: 3.942

3.  Protein arginine methyltransferase 5 (Prmt5) promotes gene expression of peroxisome proliferator-activated receptor γ2 (PPARγ2) and its target genes during adipogenesis.

Authors:  Scott E LeBlanc; Silvana Konda; Qiong Wu; Yu-Jie Hu; Christine M Oslowski; Saïd Sif; Anthony N Imbalzano
Journal:  Mol Endocrinol       Date:  2012-02-23

4.  Epigenetic patterns of two gene promoters (TNF-α and PON) in stroke considering obesity condition and dietary intake.

Authors:  A M Gómez-Uriz; E Goyenechea; J Campión; A de Arce; M T Martinez; B Puchau; F I Milagro; I Abete; J A Martínez; A Lopez de Munain
Journal:  J Physiol Biochem       Date:  2014-02-07       Impact factor: 4.158

5.  The FBXL10/KDM2B scaffolding protein associates with novel polycomb repressive complex-1 to regulate adipogenesis.

Authors:  Takeshi Inagaki; Satoshi Iwasaki; Yoshihiro Matsumura; Takeshi Kawamura; Toshiya Tanaka; Yohei Abe; Ayumu Yamasaki; Yuya Tsurutani; Ayano Yoshida; Yoko Chikaoka; Kanako Nakamura; Kenta Magoori; Ryo Nakaki; Timothy F Osborne; Kiyoko Fukami; Hiroyuki Aburatani; Tatsuhiko Kodama; Juro Sakai
Journal:  J Biol Chem       Date:  2014-12-22       Impact factor: 5.157

6.  Diet high in fructose promotes liver steatosis and hepatocyte apoptosis in C57BL/6J female mice: Role of disturbed lipid homeostasis and increased oxidative stress.

Authors:  Youngshim Choi; Mohamed A Abdelmegeed; Byoung-Joon Song
Journal:  Food Chem Toxicol       Date:  2017-03-01       Impact factor: 6.023

7.  Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice.

Authors:  Harshini Neelakantan; Virginia Vance; Michael D Wetzel; Hua-Yu Leo Wang; Stanton F McHardy; Celeste C Finnerty; Jonathan D Hommel; Stanley J Watowich
Journal:  Biochem Pharmacol       Date:  2017-11-15       Impact factor: 5.858

8.  RANK/RANKL/OPG pathway is an important for the epigenetic regulation of obesity.

Authors:  Rasime Kalkan; Eda Becer
Journal:  Mol Biol Rep       Date:  2019-07-30       Impact factor: 2.316

Review 9.  An assessment of molecular pathways of obesity susceptible to nutrient, toxicant and genetically induced epigenetic perturbation.

Authors:  Jing Xue; Folami Y Ideraabdullah
Journal:  J Nutr Biochem       Date:  2015-10-23       Impact factor: 6.048

10.  Uteroplacental Insufficiency with Hypoxia Upregulates Placental PPARγ-KMT5A Axis in the Rat.

Authors:  Emily Barrett; Amy Loverin; Haimei Wang; Michelle Carlson; Tricia D Larsen; Mariana M Almeida; Jenna Whitman; Michelle L Baack; Lisa A Joss-Moore
Journal:  Reprod Sci       Date:  2021-01-04       Impact factor: 3.060
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