| Literature DB >> 16889775 |
Vincent A van Beelen1, Jac M M J G Aarts, Astrid Reus, Hans Mooibroek, Lolke Sijtsma, Dirk Bosch, Ivonne M C M Rietjens, Gerrit M Alink.
Abstract
In this study the n-3 polyunsaturated fatty acids (PUFAs) eicosapentaenoic acid and docosahexaenoic acid appear to be effective inducers of electrophile-responsive element (EpRE) regulated genes, whereas the n-6 PUFA arachidonic acid is not. These n-3 PUFAs need to be oxidized to induce EpRE-regulated gene expression, as the antioxidant vitamin E can partially inhibit the PUFA induced dose-dependent effect. Results were obtained using a reporter gene assay, real-time RT-PCR and enzyme activity assays. The induction of EpRE-regulated phase II genes by n-3 PUFAs may be a major pathway by which n-3 PUFAs, in contrast to n-6 PUFAs, are chemopreventive and anticarcinogenic.Entities:
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Year: 2006 PMID： 16889775 DOI： 10.1016/j.febslet.2006.07.028
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124