Literature DB >> 1688879

Glutamine synthetase in the central nervous system is not confined to astrocytes.

W Cammer1.   

Abstract

Glutamine synthetase (GS) immunoreactivity is frequently used as an astroglial 'marker'. However, when sections of adult rat spinal cords were immunostained with antibodies against sheep glutamine synthetase, intense immunofluorescence was observed in cells resembling oligodendrocytes. In white matter in the rat brain GS immunostaining was also found in ovoid oligodendrocyte-like cells, whereas in gray matter in the same tissue sections GS immunostaining was found in astrocytes. Like the antibodies against sheep GS, antibodies against rat GS also immunostained putative oligodendrocytes, and colocalization with 2',3'-cyclic nucleotide-3'-phosphohydrolase in spinal cord supported the designation of the GS-positive cells as oligodendrocytes.

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Year:  1990        PMID： 1688879     DOI： 10.1016/0165-5728(90)90088-5

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  24 in total

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Review 5.  Physiology of Astroglia.

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Journal:  Anat Embryol (Berl)       Date:  1991

7.  15N n.m.r. measurement of the in vivo rate of glutamine synthesis and utilization at steady state in the brain of the hyperammonaemic rat.

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Journal:  Neurochem Res       Date:  1991-02       Impact factor: 3.996

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Journal:  Cereb Cortex       Date:  2014-07-17       Impact factor: 5.357
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