Literature DB >> 16888187

PACAP enhances mouse urinary bladder contractility and is upregulated in micturition reflex pathways after cystitis.

Gerald M Herrera1, Karen M Braas, Victor May, Margaret A Vizzard.   

Abstract

Pituitary adenylate cyclase-activating polypeptide (PACAP) elicits a transient contraction, sustained increase in the amplitude of spontaneous phasic contractions, and significantly increases the amplitude of nerve-mediated contractions in mouse urinary bladder smooth muscle (UBSM) strips. PACAP immunoreactivity (IR) is increased in micturition reflex pathways following cystitis. PACAP may contribute to altered sensation and bladder overactivity in the chronic bladder inflammatory syndrome, interstitial cystitis.

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Year:  2006        PMID： 16888187     DOI： 10.1196/annals.1317.040

Source DB:  PubMed          Journal:  Ann N Y Acad Sci        ISSN： 0077-8923            Impact factor:   5.691


  13 in total

1.  Effects of intrathecal administration of pituitary adenylate cyclase activating polypeptide on lower urinary tract functions in rats with intact or transected spinal cords.

Authors:  Mitsuharu Yoshiyama; William C de Groat
Journal:  Exp Neurol       Date:  2008-03-07       Impact factor: 5.330

2.  Bladder dysfunction and altered somatic sensitivity in PACAP-/- mice.

Authors:  Victor May; Margaret A Vizzard
Journal:  J Urol       Date:  2010-02       Impact factor: 7.450

3.  PACAP/VIP and receptor characterization in micturition pathways in mice with overexpression of NGF in urothelium.

Authors:  Beatrice M Girard; Susan E Malley; Karen M Braas; Victor May; Margaret A Vizzard
Journal:  J Mol Neurosci       Date:  2010-05-07       Impact factor: 3.444

4.  PACAP-mediated ATP release from rat urothelium and regulation of PACAP/VIP and receptor mRNA in micturition pathways after cyclophosphamide (CYP)-induced cystitis.

Authors:  Beatrice M Girard; Amanda Wolf-Johnston; Karen M Braas; Lori A Birder; Victor May; Margaret A Vizzard
Journal:  J Mol Neurosci       Date:  2008-06-19       Impact factor: 3.444

Review 5.  The role of vasoactive intestinal polypeptide and pituitary adenylate cyclase-activating polypeptide in the neural pathways controlling the lower urinary tract.

Authors:  Mitsuharu Yoshiyama; William C de Groat
Journal:  J Mol Neurosci       Date:  2008-08-02       Impact factor: 3.444

Review 6.  Treatment approaches for painful bladder syndrome/interstitial cystitis.

Authors:  Theoharis C Theoharides
Journal:  Drugs       Date:  2007       Impact factor: 9.546

7.  Effects of PACAP on survival and renal morphology in rats subjected to renal ischemia/reperfusion.

Authors:  Peter Szakaly; Peter Kiss; Andrea Lubics; Tamas Magyarlaki; Andrea Tamas; Boglarka Racz; Istvan Lengvari; Gabor Toth; Dora Reglodi
Journal:  J Mol Neurosci       Date:  2008-05-14       Impact factor: 3.444

8.  Intravesical PAC1 Receptor Antagonist, PACAP(6-38), Reduces Urinary Bladder Frequency and Pelvic Sensitivity in NGF-OE Mice.

Authors:  Beatrice M Girard; Susan E Malley; Morgan M Mathews; Victor May; Margaret A Vizzard
Journal:  J Mol Neurosci       Date:  2016-05-04       Impact factor: 3.444

9.  Effects of CYP-Induced Cystitis on Growth Factors and Associated Receptor Expression in Micturition Pathways in Mice with Chronic Overexpression of NGF in Urothelium.

Authors:  Beatrice M Girard; Susan Malley; Victor May; Margaret A Vizzard
Journal:  J Mol Neurosci       Date:  2016-06-03       Impact factor: 3.444

Review 10.  PACAP/PAC1 Expression and Function in Micturition Pathways.

Authors:  Jacqueline Ojala; Katharine Tooke; Harrison Hsiang; Beatrice M Girard; Victor May; Margaret A Vizzard
Journal:  J Mol Neurosci       Date:  2018-09-27       Impact factor: 3.444
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