Literature DB >> 168868

Phosphotriesters in rat liver deoxyribonucleic acid after the administration of the carcinogen NN-dimethylnitrosamine in vivo.

P J O'Connor, G P Marigison, A W Craig.   

Abstract

After treatment with NN-di[14C]methylnitrosamine, samples of DNA were isolated from rat livers by a conventional phenol procedure and examined for the presence of phosphotriesters. A method of capable of detecting relatively small amounts of 14C-labelled phosphotriesters was developed and used to establish that these products account for 10-12% of the total methylation pattern found after treatment with this agent in vitro. The significance of the presence of phosphotriesters in DNA is discussed.

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Year:  1975        PMID： 168868      PMCID： PMC1165247          DOI： 10.1042/bj1450475

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  17 in total

1.  Nucleic acids.

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Journal:  Annu Rev Biochem       Date:  1955       Impact factor: 23.643

2.  The reaction of nucleic acids with mustard gas.

Authors:  D T Elmore; J M Gulland; D O Jordan; H F Taylor
Journal:  Biochem J       Date:  1948       Impact factor: 3.857

3.  The chromatographic identification of some biologically important phosphate esters.

Authors:  R S BANDURSKI; B AXELROD
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

4.  The reaction of alkylating agents with bacteriophage R17. Biological effects of phosphotriester formation.

Authors:  K V Shooter; R Howse; R K Merrifield
Journal:  Biochem J       Date:  1974-02       Impact factor: 3.857

5.  The molecular basis for biological inactivation of nucleic acids. The action of methylating agents on the ribonucleic acid-containing bacteriophage R17.

Authors:  K V Shooter; R Howse; S A Shah; P D Lawley
Journal:  Biochem J       Date:  1974-02       Impact factor: 3.857

6.  Methylated polydeoxyribocytidylic acid templates for RNA polymerase.

Authors:  D B Ludlum
Journal:  Biochim Biophys Acta       Date:  1971-10

7.  Ethylation of polyadenylic acid.

Authors:  D B Ludlum
Journal:  Biochim Biophys Acta       Date:  1969-02-18

8.  Differences in the patterns of methylation in rat liver ribosomal ribonucleic acid after reaction in vivo with methyl methanesulphonate and NN-dimethylnitrosamine.

Authors:  P J O'Connor; M J Capps; A W Craig; P D Lawley; S A Shah
Journal:  Biochem J       Date:  1972-09       Impact factor: 3.857

9.  Alkylation of phosphates and stability of phosphate triesters in DNA.

Authors:  P Bannon; W Verly
Journal:  Eur J Biochem       Date:  1972-11-21

10.  Reaction of N-methyl-N-nitrosourea (MNUA) with 32P-labelled DNA: evidence for formation of phosphotriesters.

Authors:  P D Lawley
Journal:  Chem Biol Interact       Date:  1973-08       Impact factor: 5.192
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  10 in total

1.  Alkylation of deoxyribonucleic acid by carcinogens dimethyl sulphate, ethyl methanesulphonate, N-ethyl-N-nitrosourea and N-methyl-N-nitrosourea. Relative reactivity of the phosphodiester site thymidylyl(3'-5')thymidine.

Authors:  D H Swenson; P D Lawley
Journal:  Biochem J       Date:  1978-06-01       Impact factor: 3.857

Review 2.  Nucleic acid adducts of chemical carcinogens and mutagens.

Authors:  K Hemminki
Journal:  Arch Toxicol       Date:  1983-04       Impact factor: 5.153

3.  Role of apurinic sites in the resistance of methylated oligodeoxyribonucleotides to degradation by spleen exonuclease.

Authors:  G P Margison; P J O'Connor
Journal:  Biochem J       Date:  1975-11       Impact factor: 3.857

4.  Methylated purines in the deoxyribonucleic acid of various Syrian-golden-hamster tissues after administration of a hepatocarcinogenic dose of dimethylnitrosamine.

Authors:  G P Margison; J M Margison; R Montesano
Journal:  Biochem J       Date:  1976-09-01       Impact factor: 3.857

5.  Interactions of trichloroethylene with DNA in vitro and with RNA and DNA of various mouse tissues in vivo.

Authors:  K Bergman
Journal:  Arch Toxicol       Date:  1983-11       Impact factor: 5.153

6.  The methylation of DNA in regenerating rat liver.

Authors:  T A Lawson
Journal:  Z Krebsforsch Klin Onkol Cancer Res Clin Oncol       Date:  1977-11-18

7.  Effect of treatment in vivo with N,N-dimethylnitrosamine or methyl methanesulphonate on the cytoplasmic DNA polymerase of regenerating rat liver.

Authors:  J G Salisbury; P J O'Connor
Journal:  Nucleic Acids Res       Date:  1976-06       Impact factor: 16.971

8.  Cloning of the E. coli O6-methylguanine and methylphosphotriester methyltransferase gene using a functional DNA repair assay.

Authors:  G P Margison; D P Cooper; J Brennand
Journal:  Nucleic Acids Res       Date:  1985-03-25       Impact factor: 16.971

9.  Partial hepatectomy and toxicity of dimethyl-nitrosamine and carbon tetrachloride, in relation to the carcinogenic action of dimethylnitrosamine.

Authors:  A W Pound; T A Lawson
Journal:  Br J Cancer       Date:  1975-11       Impact factor: 7.640

10.  Influence of carbon tetrachloride on induction of tumours of the liver and kidneys in mice by netrosamines.

Authors:  A W Pound
Journal:  Br J Cancer       Date:  1978-01       Impact factor: 7.640
  10 in total

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