Literature DB >> 16885019

Enhanced histone acetylation and transcription: a dynamic perspective.

Alison L Clayton1, Catherine A Hazzalin, Louis C Mahadevan.   

Abstract

Stably enhanced histone acetylation has long been regarded as a condition of transcriptionally active genes. Recent papers suggest a more dynamic model, with rapid turnover of acetylation observed at nontranscribing "poised" genes and shown to be an important determinant of transcriptional efficiency upon gene induction. Are these "special cases," restricted to specific genes and specific types of histone modifications, or could the entire panoply of histone modifications associated with transcription now be revisited with a much more dynamic perspective?

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Year:  2006        PMID： 16885019     DOI： 10.1016/j.molcel.2006.06.017

Source DB:  PubMed          Journal:  Mol Cell        ISSN： 1097-2765            Impact factor:   17.970


  195 in total

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Review 10.  Alcohol-induced protein hyperacetylation: mechanisms and consequences.

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