Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Cytokines regulate postnatal hematopoietic stem cell expansion: opposing roles of thrombopoietin and LNK.

Literature DB >> 16882979

Cytokines regulate postnatal hematopoietic stem cell expansion: opposing roles of thrombopoietin and LNK.

Natalija Buza-Vidas¹, Jennifer Antonchuk, Hong Qian, Robert Månsson, Sidinh Luc, Sasan Zandi, Kristina Anderson, Satoshi Takaki, Jens M Nygren, Christina T Jensen, Sten Eirik W Jacobsen.

Abstract

The role of cytokines as regulators of hematopoietic stem cell (HSC) expansion remains elusive. Herein, we identify thrombopoietin (THPO) and the cytokine signaling inhibitor LNK, as opposing physiological regulators of HSC expansion. Lnk(-/-) HSCs continue to expand postnatally, up to 24-fold above normal by 6 mo of age. Within the stem cell compartment, this expansion is highly selective for self-renewing long-term HSCs (LT-HSCs), which show enhanced THPO responsiveness. Lnk(-/-) HSC expansion is dependent on THPO, and 12-wk-old Lnk(-/-)Thpo(-/-) mice have 65-fold fewer LT-HSCs than Lnk(-/-) mice. Expansions of multiple myeloid, but not lymphoid, progenitors in Lnk(-/-) mice also proved THPO-dependent.

Entities: Gene Species

Mesh：

Substances：

Year: 2006 PMID： 16882979 PMCID： PMC1536053 DOI： 10.1101/gad.385606

Source DB: PubMed Journal: Genes Dev ISSN： 0890-9369 Impact factor: 11.361

36 in total

1. Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation.

Authors: Anna V Molofsky; Ricardo Pardal; Toshihide Iwashita; In-Kyung Park; Michael F Clarke; Sean J Morrison
Journal: Nature Date: 2003-10-22 Impact factor: 49.962

2. A direct measurement of the radiation sensitivity of normal mouse bone marrow cells.

Authors: J E TILL; E A McCULLOCH
Journal: Radiat Res Date: 1961-02 Impact factor: 2.841

3. Defining 'stemness': Notch and Wnt join forces?

Authors: Sten Eirik W Jacobsen
Journal: Nat Immunol Date: 2005-03 Impact factor: 25.606

Review 4. Differentiation and proliferation of hematopoietic stem cells.

Authors: M Ogawa
Journal: Blood Date: 1993-06-01 Impact factor: 22.113

5. Quantification of self-renewal capacity in single hematopoietic stem cells from normal and Lnk-deficient mice.

Authors: Hideo Ema; Kazuhiro Sudo; Jun Seita; Azusa Matsubara; Yohei Morita; Mitsujiro Osawa; Kiyoshi Takatsu; Satoshi Takaki; Hiromitsu Nakauchi
Journal: Dev Cell Date: 2005-06 Impact factor: 12.270

6. Mpl ligand prevents lethal myelosuppression by inhibiting p53-dependent apoptosis.

Authors: T I Pestina; J L Cleveland; C Yang; G P Zambetti; C W Jackson
Journal: Blood Date: 2001-10-01 Impact factor: 22.113

7. Hematopoietic stem cell deficiencies in mice lacking c-Mpl, the receptor for thrombopoietin.

Authors: S Kimura; A W Roberts; D Metcalf; W S Alexander
Journal: Proc Natl Acad Sci U S A Date: 1998-02-03 Impact factor: 11.205

8. Lnk inhibits Tpo-mpl signaling and Tpo-mediated megakaryocytopoiesis.

Authors: Wei Tong; Harvey F Lodish
Journal: J Exp Med Date: 2004-08-30 Impact factor: 14.307

9. Studies of W mutant mice provide evidence for alternate mechanisms capable of activating hematopoietic stem cells.

Authors: C L Miller; V I Rebel; M E Lemieux; C D Helgason; P M Lansdorp; C J Eaves
Journal: Exp Hematol Date: 1996-02 Impact factor: 3.084

10. Physiological regulation of early and late stages of megakaryocytopoiesis by thrombopoietin.

Authors: F J de Sauvage; K Carver-Moore; S M Luoh; A Ryan; M Dowd; D L Eaton; M W Moore
Journal: J Exp Med Date: 1996-02-01 Impact factor: 14.307

48 in total

1. Lnk constrains myeloproliferative diseases in mice.

Authors: Alexey Bersenev; Chao Wu; Joanna Balcerek; Jiang Jing; Mondira Kundu; Gerd A Blobel; Kudakwashe R Chikwava; Wei Tong
Journal: J Clin Invest Date: 2010-05-10 Impact factor: 14.808

2. Regulation of hematopoietic stem cells by their mature progeny.

Authors: Carolyn A de Graaf; Maria Kauppi; Tracey Baldwin; Craig D Hyland; Donald Metcalf; Tracy A Willson; Marina R Carpinelli; Gordon K Smyth; Warren S Alexander; Douglas J Hilton
Journal: Proc Natl Acad Sci U S A Date: 2010-11-29 Impact factor: 11.205

Review 3. Hematopoietic stem cell: self-renewal versus differentiation.

Authors: Jun Seita; Irving L Weissman
Journal: Wiley Interdiscip Rev Syst Biol Med Date: 2010 Nov-Dec

Review 4. Erythropoietin receptor response circuits.

Authors: Don M Wojchowski; Pradeep Sathyanarayana; Arvind Dev
Journal: Curr Opin Hematol Date: 2010-05 Impact factor: 3.284

5. Cytokines regulating hematopoietic stem cell function.

Authors: Cheng C Zhang; Harvey F Lodish
Journal: Curr Opin Hematol Date: 2008-07 Impact factor: 3.284

6. The role of the chromatin remodeler Mi-2beta in hematopoietic stem cell self-renewal and multilineage differentiation.

Authors: Toshimi Yoshida; Idit Hazan; Jiangwen Zhang; Samuel Y Ng; Taku Naito; Hugo J Snippert; Elizabeth J Heller; Xiaoqing Qi; Lee N Lawton; Christine J Williams; Katia Georgopoulos
Journal: Genes Dev Date: 2008-05-01 Impact factor: 11.361