Literature DB >> 16880973

Glycosyltransferases involved in the biosynthesis of biologically active natural products that contain oligosaccharides.

Andriy Luzhetskyy1, Andreas Vente, Andreas Bechthold.   

Abstract

A unique characteristic of carbohydrates is their structural diversity which is greater than that of many other classes of biological compounds. Carbohydrate-containing natural products show many different biological activities and some of them have been developed as drugs for medical use. The biosynthesis of carbohydrate-containing natural products is catalysed by glycosyltransferases. In this review we will present information on the function of glycosyltransferases involved in the biosynthesis of oligosaccharide antibiotics focusing especially on urdamycins and landomycins, two angucycline antibiotics with interesting antitumor activities. We will also discuss the use of glycosyltransferases in combinatorial biosynthesis to generate new "hybrid" antibiotics.

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Year:  2005        PMID： 16880973     DOI： 10.1039/b503215f

Source DB:  PubMed          Journal:  Mol Biosyst        ISSN： 1742-2051


  11 in total

1.  Landomycins P-W, cytotoxic angucyclines from Streptomyces cyanogenus S-136.

Authors:  Khaled A Shaaban; Sowmyalakshmi Srinivasan; Raj Kumar; Chendil Damodaran; Jürgen Rohr
Journal:  J Nat Prod       Date:  2010-12-28       Impact factor: 4.050

2.  On the acceptor substrate of C-glycosyltransferase UrdGT2: three prejadomycin C-Glycosides from an engineered mutant of Streptomyces globisporus 1912 DeltalndE(urdGT2).

Authors:  Irfan Baig; Madan Kharel; Anton Kobylyanskyy; Lili Zhu; Yuriy Rebets; Bohdan Ostash; Andriy Luzhetskyy; Andreas Bechthold; Victor A Fedorenko; Jürgen Rohr
Journal:  Angew Chem Int Ed Engl       Date:  2006-11-27       Impact factor: 15.336

3.  De novo asymmetric synthesis of fridamycin E.

Authors:  Qian Chen; Michael Mulzer; Pei Shi; Penny J Beuning; Geoffrey W Coates; George A O'Doherty
Journal:  Org Lett       Date:  2011-11-22       Impact factor: 6.005

4.  DE NOVO ASYMMETRIC APPROACH TO THE DISACCHARIDE PORTION OF SCH-47554.

Authors:  Xiaomei Yu; Miaosheng Li; George A O'Doherty
Journal:  Heterocycles       Date:  2010-09-15       Impact factor: 0.831

Review 5.  Delineation of gilvocarcin, jadomycin, and landomycin pathways through combinatorial biosynthetic enzymology.

Authors:  Madan K Kharel; Jürgen Rohr
Journal:  Curr Opin Chem Biol       Date:  2012-03-30       Impact factor: 8.822

6.  Surprising production of a new urdamycin derivative by S. fradiae Delta urdQ/R.

Authors:  M Fedoryshyn; M Nur-e-Alam; L Zhu; A Luzhetskyy; J Rohr; A Bechthold
Journal:  J Biotechnol       Date:  2007-02-28       Impact factor: 3.307

7.  Formation and attachment of the deoxysugar moiety and assembly of the gene cluster for caprazamycin biosynthesis.

Authors:  Leonard Kaysser; Emmanuel Wemakor; Stefanie Siebenberg; Jose A Salas; Jae Kyung Sohng; Bernd Kammerer; Bertolt Gust
Journal:  Appl Environ Microbiol       Date:  2010-04-23       Impact factor: 4.792

8.  Convergent de novo synthesis of vineomycinone B2 methyl ester.

Authors:  Qian Chen; Yashan Zhong; George A O'Doherty
Journal:  Chem Commun (Camb)       Date:  2013-08-04       Impact factor: 6.222

9.  11-Deoxylandomycinone and landomycins X-Z, new cytotoxic angucyclin(on)es from a Streptomyces cyanogenus K62 mutant strain.

Authors:  Khaled A Shaaban; Chris Stamatkin; Chendil Damodaran; Jürgen Rohr
Journal:  J Antibiot (Tokyo)       Date:  2010-10-27       Impact factor: 2.649

10.  Lysoquinone-TH1, a New Polyphenolic Tridecaketide Produced by Expressing the Lysolipin Minimal PKS II in Streptomyces albus.

Authors:  Torben Hofeditz; Claudia Eva-Maria Unsin; Jutta Wiese; Johannes F Imhoff; Wolfgang Wohlleben; Stephanie Grond; Tilmann Weber
Journal:  Antibiotics (Basel)       Date:  2018-06-28
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