Literature DB >> 16880926

Small molecules in an RNAi world.

Ulrike S Eggert1, Christine M Field, Timothy J Mitchison.   

Abstract

In this Opinion, we compare and contrast small molecules and RNAi. We discuss the advantages and disadvantages of both technologies focusing on timing, specificity, dose and therapeutic use.

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Year:  2005        PMID： 16880926     DOI： 10.1039/b515335b

Source DB:  PubMed          Journal:  Mol Biosyst        ISSN： 1742-2051


  14 in total

Review 1.  Single-cell and multivariate approaches in genetic perturbation screens.

Authors:  Prisca Liberali; Berend Snijder; Lucas Pelkmans
Journal:  Nat Rev Genet       Date:  2014-12-02       Impact factor: 53.242

2.  The why and how of phenotypic small-molecule screens.

Authors:  Ulrike S Eggert
Journal:  Nat Chem Biol       Date:  2013-04       Impact factor: 15.040

Review 3.  Vigilance and validation: Keys to success in RNAi screening.

Authors:  Frederic D Sigoillot; Randall W King
Journal:  ACS Chem Biol       Date:  2010-12-28       Impact factor: 5.100

Review 4.  Small molecule probes of cellular pathways and networks.

Authors:  Adam B Castoreno; Ulrike S Eggert
Journal:  ACS Chem Biol       Date:  2010-11-18       Impact factor: 5.100

5.  Small molecules discovered in a pathway screen target the Rho pathway in cytokinesis.

Authors:  Adam B Castoreno; Yegor Smurnyy; Angelica D Torres; Martha S Vokes; Thouis R Jones; Anne E Carpenter; Ulrike S Eggert
Journal:  Nat Chem Biol       Date:  2010-05-02       Impact factor: 15.040

6.  The concentration of Nuf, a Rab11 effector, at the microtubule-organizing center is cell cycle regulated, dynein-dependent, and coincides with furrow formation.

Authors:  Blake Riggs; Barbara Fasulo; Anne Royou; Sarah Mische; Jian Cao; Thomas S Hays; William Sullivan
Journal:  Mol Biol Cell       Date:  2007-06-20       Impact factor: 4.138

Review 7.  RNA interference-based therapy and its delivery systems.

Authors:  Xiuhui Chen; Lingegowda S Mangala; Cristian Rodriguez-Aguayo; Xianchao Kong; Gabriel Lopez-Berestein; Anil K Sood
Journal:  Cancer Metastasis Rev       Date:  2018-03       Impact factor: 9.264

8.  Capping protein regulates actin dynamics during cytokinetic midbody maturation.

Authors:  Stephen J Terry; Federico Donà; Paul Osenberg; Jeremy G Carlton; Ulrike S Eggert
Journal:  Proc Natl Acad Sci U S A       Date:  2018-02-08       Impact factor: 11.205

9.  Modulation of CD59 expression by restrictive silencer factor-derived peptides in cancer immunotherapy for neuroblastoma.

Authors:  Rossen M Donev; Lisa C Gray; Baalasubramanian Sivasankar; Timothy R Hughes; Carmen W van den Berg; B Paul Morgan
Journal:  Cancer Res       Date:  2008-07-15       Impact factor: 12.701

10.  Structural Features of Small Molecules Targeting the RNA Repeat Expansion That Causes Genetically Defined ALS/FTD.

Authors:  Andrei Ursu; Kye Won Wang; Jessica A Bush; Shruti Choudhary; Jonathan L Chen; Jared T Baisden; Yong-Jie Zhang; Tania F Gendron; Leonard Petrucelli; Ilyas Yildirim; Matthew D Disney
Journal:  ACS Chem Biol       Date:  2020-11-16       Impact factor: 5.100
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