Literature DB >> 16880677

Cytotoxic arylnaphthalene lignans from Phyllanthus oligospermus.

Shwu-Jen Wu1, Tian-Shung Wu.   

Abstract

Three new arylnaphthalene lignans, namely phyllanthusmins A-C, together with nine known compounds were isolated and characterized from the stems and roots of Phyllanthus oligospermus by a bioassay-guided purification. The structures of the new compounds were elucidated by means of spectroscopic data interpretation. Among them, phyllanthusminA displayed significant cytotoxicity against KB and P-388 cancer cell lines.

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Year:  2006        PMID： 16880677     DOI： 10.1248/cpb.54.1223

Source DB:  PubMed          Journal:  Chem Pharm Bull (Tokyo)        ISSN： 0009-2363            Impact factor:   1.645


  9 in total

1.  Synthesis and antiproliferative activity of derivatives of the phyllanthusmin class of arylnaphthalene lignan lactones.

Authors:  John L Woodard; Andrew C Huntsman; Pratiq A Patel; Hee-Byung Chai; Ragu Kanagasabai; Soumendrakrishna Karmahapatra; Alexandria N Young; Yulin Ren; Malcolm S Cole; Denisse Herrera; Jack C Yalowich; A Douglas Kinghorn; Joanna E Burdette; James R Fuchs
Journal:  Bioorg Med Chem       Date:  2018-03-23       Impact factor: 3.641

2.  Cytotoxic and natural killer cell stimulatory constituents of Phyllanthus songboiensis.

Authors:  Yulin Ren; Chunhua Yuan; Youcai Deng; Ragu Kanagasabai; Tran Ngoc Ninh; Vuong Tan Tu; Hee-Byung Chai; Djaja D Soejarto; James R Fuchs; Jack C Yalowich; Jianhua Yu; A Douglas Kinghorn
Journal:  Phytochemistry       Date:  2015-01-14       Impact factor: 4.072

Review 3.  Arylnaphthalene lactone analogues: synthesis and development as excellent biological candidates for future drug discovery.

Authors:  Chuang Zhao; K P Rakesh; Saira Mumtaz; Balakrishna Moku; Abdullah M Asiri; Hadi M Marwani; H M Manukumar; Hua-Li Qin
Journal:  RSC Adv       Date:  2018-03-06       Impact factor: 4.036

Review 4.  Lignans: a versatile source of anticancer drugs.

Authors:  Minky Mukhija; Bhuwan Chandra Joshi; Partha Sarathi Bairy; Anurag Bhargava; Archana N Sah
Journal:  Beni Suef Univ J Basic Appl Sci       Date:  2022-06-04

5.  Phyllanthusmin Derivatives Induce Apoptosis and Reduce Tumor Burden in High-Grade Serous Ovarian Cancer by Late-Stage Autophagy Inhibition.

Authors:  Alexandria N Young; Denisse Herrera; Andrew C Huntsman; Melissa A Korkmaz; Daniel D Lantvit; Sarmistha Mazumder; Shamalatha Kolli; Christopher C Coss; Salane King; Hongyan Wang; Steven M Swanson; A Douglas Kinghorn; Xiaoli Zhang; Mitch A Phelps; Leslie N Aldrich; James R Fuchs; Joanna E Burdette
Journal:  Mol Cancer Ther       Date:  2018-07-17       Impact factor: 6.261

6.  Evaluation and structure-activity relationship analysis of a new series of arylnaphthalene lignans as potential anti-tumor agents.

Authors:  Jiaoyang Luo; Yichen Hu; Weijun Kong; Meihua Yang
Journal:  PLoS One       Date:  2014-03-27       Impact factor: 3.240

Review 7.  The Genus Phyllanthus: An Ethnopharmacological, Phytochemical, and Pharmacological Review.

Authors:  Xin Mao; Ling-Fang Wu; Hong-Ling Guo; Wen-Jing Chen; Ya-Ping Cui; Qi Qi; Shi Li; Wen-Yi Liang; Guang-Hui Yang; Yan-Yan Shao; Dan Zhu; Gai-Mei She; Yun You; Lan-Zhen Zhang
Journal:  Evid Based Complement Alternat Med       Date:  2016-04-20       Impact factor: 2.629

8.  Potent cytotoxic arylnaphthalene lignan lactones from Phyllanthus poilanei.

Authors:  Yulin Ren; Daniel D Lantvit; Youcai Deng; Ragu Kanagasabai; Judith C Gallucci; Tran Ngoc Ninh; Hee-Byung Chai; Djaja D Soejarto; James R Fuchs; Jack C Yalowich; Jianhua Yu; Steven M Swanson; A Douglas Kinghorn
Journal:  J Nat Prod       Date:  2014-06-12       Impact factor: 4.050

9.  Highly Oxygenated Limonoids and Lignans from Phyllanthus flexuosus.

Authors:  Jian-Qiang Zhao; Yan-Ming Wang; Hong-Tao Zhu; Dong Wang; Sheng-Hong Li; Rong-Rong Cheng; Chong-Ren Yang; Yi-Fei Wang; Min Xu; Ying-Jun Zhang
Journal:  Nat Prod Bioprospect       Date:  2014-07-22
  9 in total

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