| Literature DB >> 25596805 |
Yulin Ren1, Chunhua Yuan2, Youcai Deng3, Ragu Kanagasabai4, Tran Ngoc Ninh5, Vuong Tan Tu5, Hee-Byung Chai1, Djaja D Soejarto6, James R Fuchs1, Jack C Yalowich4, Jianhua Yu7, A Douglas Kinghorn8.
Abstract
A dichapetalin-type triterpenoid and a dibenzylbutyrolactone-type lignan, together with five known lignans, a known aromatic diterpenoid, and a known acylated phytosterol, were isolated from the aerial parts of Phyllanthus songboiensis, collected in Vietnam. Their structures were determined by interpretation of the spectroscopic data, and the inhibitory activity toward HT-29 human colon cancer cells of all isolates was evaluated by a cytotoxicity assay. The known arylnaphthalene lignan, (+)-acutissimalignan A, was highly cytotoxic toward HT-29 cells, with an IC50 value of 19 nM, but this compound was inactive as a DNA topoisomerase IIα (topo IIα) poison. The known phytosterol, (-)-β-sitosterol-3-O-β-D-(6-O-palmitoyl)glucopyranoside, was found to stimulate natural killer (NK) cells at a concentration of 10μM in the presence of interleukin 12 (IL-12).Entities:
Keywords: Cytotoxicity; DNA topoisomerase IIα; Lignan; Natural killer cell; Phyllanthaceae; Phyllanthus songboiensis; Phytosterol
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Year: 2015 PMID： 25596805 PMCID： PMC4333069 DOI： 10.1016/j.phytochem.2014.12.014
Source DB: PubMed Journal: Phytochemistry ISSN： 0031-9422 Impact factor: 4.072