Literature DB >> 16874532

[Cutaneous malignant melanoma. Excision margins and lymph node dissections].

G Sebastian1.   

Abstract

Excision is the treatment of choice in stage I malignant melanoma. As supported by several controlled clinical studies, reduced safety surgical margins from 0.5 to 2 cm are sufficient. Most surgical defects can be closed by simple skin flap techniques. In critical anatomic sites (e. g. face, hand, foot) micrographic surgery is the therapy of choice. Sentinel lymph node biopsy (SLNB) was proposed as a minimally-invasive procedure for the histopathologic staging of the regional lymph nodes. Today SLNB is standard in the diagnostic approach to melanomas thicker than 1 mm. The therapeutic relevance of SLNB is unclear. The most common sign of tumor progression is involvement of regional lymph nodes. The treatment of choice in patients with neck metastases is the radical, modified or selective neck dissection. In the case of axillary metastases, levels I-III of the axillary lymph nodes are excised. With groin metastases, superficial inguinal dissection is usually preferred. There are no randomized controlled trials comparing the outcome of combined inguinal and pelvic lymph node dissection and superficial inguinal lymph node dissection.

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Year:  2006        PMID: 16874532     DOI: 10.1007/s00105-006-1187-7

Source DB:  PubMed          Journal:  Hautarzt        ISSN: 0017-8470            Impact factor:   0.751


  23 in total

1.  Patterns of local horizontal spread of melanomas: consequences for surgery and histopathologic investigation.

Authors:  H Breuninger; B Schlagenhauff; W Stroebel; G Schaumburg-Lever; G Rassner
Journal:  Am J Surg Pathol       Date:  1999-12       Impact factor: 6.394

Review 2.  [Safety margins in the excision of primary malignant melanoma. Proposals based on controlled clinical trials].

Authors:  A Hauschild; S Eiling; S Lischner; T C Haacke; E Christophers
Journal:  Hautarzt       Date:  2001-11       Impact factor: 0.751

3.  Thin stage I primary cutaneous malignant melanoma. Comparison of excision with margins of 1 or 3 cm.

Authors:  U Veronesi; N Cascinelli; J Adamus; C Balch; D Bandiera; A Barchuk; R Bufalino; P Craig; J De Marsillac; J C Durand
Journal:  N Engl J Med       Date:  1988-05-05       Impact factor: 91.245

4.  Thickness, cross-sectional areas and depth of invasion in the prognosis of cutaneous melanoma.

Authors:  A Breslow
Journal:  Ann Surg       Date:  1970-11       Impact factor: 12.969

5.  Long-term results of a prospective surgical trial comparing 2 cm vs. 4 cm excision margins for 740 patients with 1-4 mm melanomas.

Authors:  C M Balch; S J Soong; T Smith; M I Ross; M M Urist; C P Karakousis; W J Temple; M C Mihm; R L Barnhill; W R Jewell; H J Wanebo; R Desmond
Journal:  Ann Surg Oncol       Date:  2001-03       Impact factor: 5.344

6.  A micromorphometry-based concept for routine classification of sentinel lymph node metastases and its clinical relevance for patients with melanoma.

Authors:  H Starz; B R Balda; K U Krämer; H Büchels; H Wang
Journal:  Cancer       Date:  2001-06-01       Impact factor: 6.860

7.  Does the extent of operation influence the prognosis in patients with melanoma metastatic to inguinal nodes?

Authors:  G B Mann; D G Coit
Journal:  Ann Surg Oncol       Date:  1999 Apr-May       Impact factor: 5.344

8.  Long term results of a randomized study by the Swedish Melanoma Study Group on 2-cm versus 5-cm resection margins for patients with cutaneous melanoma with a tumor thickness of 0.8-2.0 mm.

Authors:  G Cohn-Cedermark; L E Rutqvist; R Andersson; M Breivald; C Ingvar; H Johansson; P E Jönsson; L Krysander; C Lindholm; U Ringborg
Journal:  Cancer       Date:  2000-10-01       Impact factor: 6.860

9.  Resection margins of 2 versus 5 cm for cutaneous malignant melanoma with a tumor thickness of 0.8 to 2.0 mm: randomized study by the Swedish Melanoma Study Group.

Authors:  U Ringborg; R Andersson; J Eldh; B Glaumann; L Hafström; S Jacobsson; P E Jönsson; H Johansson; L Krysander; B Lagerlöf
Journal:  Cancer       Date:  1996-05-01       Impact factor: 6.860

10.  Excision margins in high-risk malignant melanoma.

Authors:  J Meirion Thomas; Julia Newton-Bishop; Roger A'Hern; Gill Coombes; Michael Timmons; Judy Evans; Martin Cook; Jeffery Theaker; Mary Fallowfield; Trevor O'Neill; Wlodek Ruka; Judith M Bliss
Journal:  N Engl J Med       Date:  2004-02-19       Impact factor: 91.245

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  1 in total

1.  [Exophytic tumor of the neck].

Authors:  J Linke; M Neudert; A Forberger; T Zahnert
Journal:  HNO       Date:  2012-10       Impact factor: 1.284

  1 in total

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