Literature DB >> 16874381

High-performance flow-focusing geometry for spontaneous generation of monodispersed droplets.

Levent Yobas1, Stefan Martens, Wee-Liat Ong, Nagarajan Ranganathan.   

Abstract

A high-performance flow-focusing geometry for spontaneous generation of monodispersed droplets is demonstrated. In this geometry, a two-phase flow is forced through a circular orifice integrated inside a silicon-based microchannel. The orifice with its cusp-like edge exerts a ring of maximized stress around the flow and ensures controlled breakup of droplets for a wide range of flow rates, forming highly periodic and reproducible dispersions. The droplet generation can be remarkably rapid, exceeding 10(4) s(-1) for water-in-oil droplets and reaching 10(3) s(-1) for oil-in-water droplets, being largely controlled by flow rate of the continuous phase. The droplet diameter and generation frequency are compared against a quasi-equilibrium model based on the critical Capillary number. The droplets are obtained despite the low Capillary number, below the critical value identified by the ratio of viscosities between the two phases and simple shear-flow.

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Year:  2006        PMID: 16874381     DOI: 10.1039/b602240e

Source DB:  PubMed          Journal:  Lab Chip        ISSN: 1473-0189            Impact factor:   6.799


  27 in total

1.  Microfluidic on-demand droplet generation, storage, retrieval, and merging for single-cell pairing.

Authors:  Hesam Babahosseini; Tom Misteli; Don L DeVoe
Journal:  Lab Chip       Date:  2019-01-29       Impact factor: 6.799

Review 2.  Generation and manipulation of hydrogel microcapsules by droplet-based microfluidics for mammalian cell culture.

Authors:  Haishui Huang; Yin Yu; Yong Hu; Xiaoming He; O Berk Usta; Martin L Yarmush
Journal:  Lab Chip       Date:  2017-05-31       Impact factor: 6.799

3.  Multiphase bioreaction microsystem with automated on-chip droplet operation.

Authors:  Fang Wang; Mark A Burns
Journal:  Lab Chip       Date:  2010-03-05       Impact factor: 6.799

4.  A programmable microfluidic platform for multisample injection, discretization, and droplet manipulation.

Authors:  Hesam Babahosseini; Supriya Padmanabhan; Tom Misteli; Don L DeVoe
Journal:  Biomicrofluidics       Date:  2020-02-05       Impact factor: 2.800

5.  Dripping and jetting in microfluidic multiphase flows applied to particle and fiber synthesis.

Authors:  J K Nunes; S S H Tsai; J Wan; H A Stone
Journal:  J Phys D Appl Phys       Date:  2013-03-20       Impact factor: 3.207

6.  High-speed droplet generation on demand driven by pulse laser-induced cavitation.

Authors:  Sung-Yong Park; Ting-Hsiang Wu; Yue Chen; Michael A Teitell; Pei-Yu Chiou
Journal:  Lab Chip       Date:  2011-02-02       Impact factor: 6.799

7.  On-the-fly exchangeable microfluidic nozzles for facile production of various monodisperse micromaterials.

Authors:  Tom Kamperman; Bas van Loo; Melvin Gurian; Sieger Henke; Marcel Karperien; Jeroen Leijten
Journal:  Lab Chip       Date:  2019-04-24       Impact factor: 6.799

8.  Performance of nanoliter-sized droplet-based microfluidic PCR.

Authors:  Fang Wang; Mark A Burns
Journal:  Biomed Microdevices       Date:  2009-05-28       Impact factor: 2.838

9.  A Scalable Random Access Micro-traps Array for Formation, Selective Retrieval and Capturing of Individual Droplets.

Authors:  H Babahosseini; S Padmanabhan; T Misteli; D L DeVoe
Journal:  Annu Int Conf IEEE Eng Med Biol Soc       Date:  2019-07

10.  Droplet Microfluidic Optimisation Using Micropipette Characterisation of Bio-Instructive Polymeric Surfactants.

Authors:  Charlotte A Henshaw; Adam A Dundas; Valentina Cuzzucoli Crucitti; Morgan R Alexander; Ricky Wildman; Felicity R A J Rose; Derek J Irvine; Philip M Williams
Journal:  Molecules       Date:  2021-05-31       Impact factor: 4.411

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