BACKGROUND: Gestational diabetes mellitus (GDM) is common and can have a substantial impact on fetal growth, birth weight, and morbidity. The American Diabetes Association recommends GDM testing with either a 3-h, 100-g glucose load (100 g) (criteria according to Am J Obstet Gynecol 1982;144:768-73) or a 2-h, 75-g glucose load (75g). We investigated the comparability of the 75 g and the 100g tests in the diagnosis of GDM. METHODS: From January 1997 to December 1999, in 1061 consecutive Caucasian nonobese and nondiabetic pregnant women who attended the Maternal-Fetal Medicine Unit, we performed GDM testing with a 75-g load during 2 periods of pregnancy: early (16-20 weeks) and late (26-30 weeks). Because we assumed there would be few GBM cases in women with a 1-h plasma glucose <1300 mg/L in the 75 g test, we did not retest these women. We retested the remaining women with possible or diagnosed GDM with a 100-g load within a week. RESULTS: GDM was diagnosed in 41 of 227 women with the 100-g load and 15 of 227 with the 75-g load (11 concordant); the kappa index was 0.21. At 26-31 weeks of pregnancy, 484 of 976 women (49.9%) underwent both tests. GDM was diagnosed in 60 of 484 woman with the 100-g load and in 26 of 484 with the 75-g load (13 concordant); the kappa index was 0.18. CONCLUSIONS: Among women with possible GDM in both early and late periods of pregnancy, there was only weak diagnostic agreement between results determined with 75-g and 100-g glucose loads.
BACKGROUND:Gestational diabetes mellitus (GDM) is common and can have a substantial impact on fetal growth, birth weight, and morbidity. The American Diabetes Association recommends GDM testing with either a 3-h, 100-g glucose load (100 g) (criteria according to Am J Obstet Gynecol 1982;144:768-73) or a 2-h, 75-g glucose load (75g). We investigated the comparability of the 75 g and the 100g tests in the diagnosis of GDM. METHODS: From January 1997 to December 1999, in 1061 consecutive Caucasian nonobese and nondiabetic pregnant women who attended the Maternal-Fetal Medicine Unit, we performed GDM testing with a 75-g load during 2 periods of pregnancy: early (16-20 weeks) and late (26-30 weeks). Because we assumed there would be few GBM cases in women with a 1-h plasma glucose <1300 mg/L in the 75 g test, we did not retest these women. We retested the remaining women with possible or diagnosed GDM with a 100-g load within a week. RESULTS: GDM was diagnosed in 41 of 227 women with the 100-g load and 15 of 227 with the 75-g load (11 concordant); the kappa index was 0.21. At 26-31 weeks of pregnancy, 484 of 976 women (49.9%) underwent both tests. GDM was diagnosed in 60 of 484 woman with the 100-g load and in 26 of 484 with the 75-g load (13 concordant); the kappa index was 0.18. CONCLUSIONS: Among women with possible GDM in both early and late periods of pregnancy, there was only weak diagnostic agreement between results determined with 75-g and 100-g glucose loads.
Authors: Thaddeus P Waters; Alan R Dyer; Denise M Scholtens; Sharon L Dooley; Elaine Herer; Lynn P Lowe; Jeremy J N Oats; Bengt Persson; David A Sacks; Boyd E Metzger; Patrick M Catalano Journal: Diabetes Care Date: 2016-09-15 Impact factor: 19.112
Authors: Alan T N Tita; Yinglei Lai; Mark B Landon; Susan M Ramin; Brian Casey; Ronald J Wapner; Michael W Varner; John M Thorp; Anthony Sciscione; Patrick Catalano; Margaret Harper; George R Saade; Steve N Caritis; Yoram Sorokin; Alan M Peaceman; Jorge E Tolosa Journal: Am J Perinatol Date: 2017-07-19 Impact factor: 1.862
Authors: Emily A Rosenberg; Ellen W Seely; Kaitlyn James; Juliana Arenas; Michael J Callahan; Melody Cayford; Stacey Nelson; Sarah N Bernstein; Ravi Thadhani; Camille E Powe Journal: Diabetes Res Clin Pract Date: 2021-05-23 Impact factor: 8.180
Authors: Esa M Davis; Christina M Scifres; Kaleab Abebe; Tina Costacou; Diane Comer; Patrick Catalano; Hyagriv Simhan; Matthew Freiberg; Nancy Day Journal: AJP Rep Date: 2018-10-29