Emily A Rosenberg1, Ellen W Seely2, Kaitlyn James3, Juliana Arenas4, Michael J Callahan4, Melody Cayford4, Stacey Nelson3, Sarah N Bernstein5, Ravi Thadhani6, Camille E Powe7. 1. Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Boston, MA, United States; Diabetes Unit, Massachusetts General Hospital, Boston, MA, United States; Harvard Medical School, Boston, MA, United States. 2. Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Boston, MA, United States; Harvard Medical School, Boston, MA, United States. 3. Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, MA, United States. 4. Diabetes Unit, Massachusetts General Hospital, Boston, MA, United States. 5. Harvard Medical School, Boston, MA, United States; Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, MA, United States; Division of Maternal Fetal Medicine, Massachusetts General Hospital, Boston, MA, United States. 6. Harvard Medical School, Boston, MA, United States; Mass General Brigham, Boston, MA, United States. 7. Diabetes Unit, Massachusetts General Hospital, Boston, MA, United States; Harvard Medical School, Boston, MA, United States. Electronic address: camille.powe@mgh.harvard.edu.
Abstract
AIMS: Evaluate the relationship between self-reported carbohydrate intake and oral glucose tolerance test (OGTT) results in pregnancy. METHODS: We measured carbohydrate intake using 24-hour dietary recall and performed a 2-hour 75-gram OGTT in 95 pregnant women with risk factors for gestational diabetes (GDM) at a median of 26 weeks' gestation. We tested for associations between carbohydrate intake in the 24 hours preceding the OGTT and 60-minute OGTT glucose, glucose at other timepoints, and glucose area under the curve (AUC) using linear regression, with adjustment for potential confounders. RESULTS: We observed an inverse linear relationship between carbohydrate intake (median 237 grams [interquartile range: 196, 303]) and 60-minute OGTT glucose. For every 50 gram reduction in carbohydrate intake, there was an 8.9 mg/dl increase in 60-minute OGTT glucose (P < 0.01) in an adjusted model. Lower carbohydrate intake was also associated with higher 30-minute (adjusted β = -6.5 mg/dl, P < 0.01) and 120-minute OGTT glucose (adjusted β = -8.1 mg/dl, P = 0.01) and AUC (adjusted β = -767, P < 0.01). CONCLUSIONS: Carbohydrate intake in the day preceding an OGTT in pregnancy is associated with post-load glucose values, with lower carbohydrate intake predicting higher glucose levels and higher carbohydrate intake predicting lower glucose levels. Carbohydrate restriction or excess before an OGTT may affect GDM diagnosis.
AIMS: Evaluate the relationship between self-reported carbohydrate intake and oral glucose tolerance test (OGTT) results in pregnancy. METHODS: We measured carbohydrate intake using 24-hour dietary recall and performed a 2-hour 75-gram OGTT in 95 pregnant women with risk factors for gestational diabetes (GDM) at a median of 26 weeks' gestation. We tested for associations between carbohydrate intake in the 24 hours preceding the OGTT and 60-minute OGTT glucose, glucose at other timepoints, and glucose area under the curve (AUC) using linear regression, with adjustment for potential confounders. RESULTS: We observed an inverse linear relationship between carbohydrate intake (median 237 grams [interquartile range: 196, 303]) and 60-minute OGTT glucose. For every 50 gram reduction in carbohydrate intake, there was an 8.9 mg/dl increase in 60-minute OGTT glucose (P < 0.01) in an adjusted model. Lower carbohydrate intake was also associated with higher 30-minute (adjusted β = -6.5 mg/dl, P < 0.01) and 120-minute OGTT glucose (adjusted β = -8.1 mg/dl, P = 0.01) and AUC (adjusted β = -767, P < 0.01). CONCLUSIONS: Carbohydrate intake in the day preceding an OGTT in pregnancy is associated with post-load glucose values, with lower carbohydrate intake predicting higher glucose levels and higher carbohydrate intake predicting lower glucose levels. Carbohydrate restriction or excess before an OGTT may affect GDM diagnosis.
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