Literature DB >> 16873058

FOXP3 and NFAT: partners in tolerance.

Alexander Y Rudensky1, Marc Gavin, Ye Zheng.   

Abstract

Regulatory T cells suppress autoimmune responses to self-antigens. Recent studies, including one in this issue of Cell (Wu et al., 2006), suggest that the ability of T cells to choose between launching a productive immune response, functional inactivation, or developing into regulatory T cells depends upon the interplay of the key transcriptional regulators FOXP3 and NFAT.

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Year:  2006        PMID: 16873058     DOI: 10.1016/j.cell.2006.07.005

Source DB:  PubMed          Journal:  Cell        ISSN: 0092-8674            Impact factor:   41.582


  44 in total

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