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Literature DB >> 16870794

In vitro interactions between piperaquine, dihydroartemisinin, and other conventional and novel antimalarial drugs.

Timothy M E Davis¹, Juliana Hamzah, Kenneth F Ilett, Harin A Karunajeewa, John C Reeder, Kevin T Batty, Sara Hackett, P Hugh R Barrett.

Abstract

In an in vitro assessment of antimalarial combinations, dihydroartemisinin (DHA) showed no interaction or was mildly antagonistic when combined with piperaquine, pyronaridine, or naphthoquine. Interactions between 4-aminoquinolines and related drugs were also indifferent/antagonistic. The clinical significance of mildly antagonistic DHA combinations is uncertain but may become important if parasite drug sensitivity declines.

Entities: Chemical

Mesh：

Substances：

Year: 2006 PMID： 16870794 PMCID： PMC1538683 DOI： 10.1128/AAC.00177-06

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

22 in total

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Authors: Tinh Hien Tran; Christiane Dolecek; Phuong Mai Pham; Thi Dung Nguyen; Thanh Truong Nguyen; Hong Thai Le; Thi Hoai An Dong; Tan Thanh Tran; Kasia Stepniewska; Nicholas J White; Jeremy Farrar
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Journal: Antimicrob Agents Chemother Date: 2007-04-02 Impact factor: 5.191

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6. Pharmacokinetics and pharmacodynamics of piperaquine in a murine malaria model.

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7. Role of known molecular markers of resistance in the antimalarial potency of piperaquine and dihydroartemisinin in vitro.

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8. In Silico Investigation of the Decline in Clinical Efficacy of Artemisinin Combination Therapies Due to Increasing Artemisinin and Partner Drug Resistance.

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Journal: Antimicrob Agents Chemother Date: 2018-11-26 Impact factor: 5.191

Review 9. Naphthoquine: An Emerging Candidate for Artemisinin Combination Therapy.

Authors: Brioni R Moore; Moses Laman; Sam Salman; Kevin T Batty; Madhu Page-Sharp; Francis Hombhanje; Laurens Manning; Timothy M E Davis
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Review 10. Mannich bases in medicinal chemistry and drug design.

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