| Literature DB >> 16870442 |
Guan-Sheng Jiao1, Ondrej Simo, Melissa Nagata, Sean O'Malley, Thomas Hemscheidt, Lynne Cregar, Sherri Z Millis, Mark E Goldman, Cho Tang.
Abstract
A series of mono-, di-, and tri-guanidinylated derivatives of neamine were prepared via selective guanidinylation of neamine. These molecules represent a novel scaffold as inhibitors of anthrax lethal factor zinc metalloprotease. Methods for the synthesis of these compounds are described, and structure-activity relationships among the series are analyzed. In addition, initial findings regarding the mechanism of LF inhibition for these molecules are presented.Entities:
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Year: 2006 PMID： 16870442 DOI： 10.1016/j.bmcl.2006.07.005
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823