| Literature DB >> 16870429 |
R P Tripathi1, S S Verma, Jyoti Pandey, K C Agarwal, Vinita Chaturvedi, Y K Manju, A K Srivastva, A Gaikwad, S Sinha.
Abstract
A series of 9-substituted tetrahydroacridines were synthesized by nucleophilic substitution of chloro group with different nucleophiles in 9-chlorotetrahydroacridine (2). The latter could be obtained by POCl(3) mediated cyclization of the intermediate enamine, which in turn, was prepared by acid catalyzed condensation of anthranilic acid and cyclohexanone. Most of the compounds on antitubercular evaluation against M. tuberculosis H37 Rv and H37 Ra strains exhibited potent activities with MIC 6.125-0.78 microg/mL comparable to the standard drugs.Entities:
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Year: 2006 PMID： 16870429 DOI： 10.1016/j.bmcl.2006.07.025
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823