Literature DB >> 16867594

Mitomycin antitumour agents: a review of their physico-chemical and analytical properties and stability.

J H Beijnen1, H Lingeman, H A Van Munster, W J Underberg.   

Abstract

The review enumerates the physico-chemical and analytical properties of mitomycin antitumour antibiotics, of which mitomycin C is the most important representative. After a short overview of the position of the compounds in oncology the following subjects will be discussed: structural features, prototropic properties, spectroscopy (UV-VIS, ORD, CD, IR, NMR, MS), chromatography and electrochemistry. The chemical stability and aspects of the mechanism of action of the compounds are also discussed. The last part of the review surveys the analysis of mitomycin C in biological fluids.

Entities:  

Year:  1986        PMID： 16867594     DOI： 10.1016/0731-7085(86)80050-4

Source DB:  PubMed          Journal:  J Pharm Biomed Anal        ISSN： 0731-7085            Impact factor:   3.935


  8 in total

1.  Cloning and analysis of a locus (mcr) involved in mitomycin C resistance in Streptomyces lavendulae.

Authors:  P R August; M C Flickinger; D H Sherman
Journal:  J Bacteriol       Date:  1994-07       Impact factor: 3.490

Review 2.  Natural products synthesis: enabling tools to penetrate Nature's secrets of biogenesis and biomechanism.

Authors:  Robert M Williams
Journal:  J Org Chem       Date:  2011-04-12       Impact factor: 4.354

3.  Purity determinations in the bulk drug of the novel indoloquinone antitumor agent EO9.

Authors:  J D Jonkman-de Vries; J J Kettenes-van den Bosch; R E Henrar; A Bult; J H Beijnen
Journal:  Invest New Drugs       Date:  1996       Impact factor: 3.850

4.  Elucidation of the Reaction Mechanism of C2 + N1 Aziridination from Tetracarbene Iron Catalysts.

Authors:  Sara B Isbill; Preeti P Chandrachud; Jesse L Kern; David M Jenkins; Sharani Roy
Journal:  ACS Catal       Date:  2019-05-31       Impact factor: 13.084

5.  Kinetics and mechanism of the degradation of 1a-acetylmitomycin C in aqueous solution.

Authors:  W J Underberg; J H Beijnen
Journal:  Pharm World Sci       Date:  1993-06-18

Review 6.  Intravesical treatments of bladder cancer: review.

Authors:  Zancong Shen; Tong Shen; M Guillaume Wientjes; Michael A O'Donnell; Jessie L-S Au
Journal:  Pharm Res       Date:  2008-03-28       Impact factor: 4.200

Review 7.  A review of the stability and compatibility of antineoplastic drugs for multiple-drug infusions.

Authors:  D A Williams; J Lokich
Journal:  Cancer Chemother Pharmacol       Date:  1992       Impact factor: 3.333

8.  In vitro and in vivo studies of pirarubicin-loaded SWNT for the treatment of bladder cancer.

Authors:  Gang Chen; Yunfeng He; Xiaohou Wu; Yao Zhang; Chunli Luo; Peng Jing
Journal:  Braz J Med Biol Res       Date:  2012-07-12       Impact factor: 2.590
  8 in total

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