Literature DB >> 168641

Acetaldehyde oxidation by hepatic mitochondria: decrease after chronic ethanol consumption.

Y Hasumura, R Teschke, C S Lieber.   

Abstract

Prolonged consumption of ethanol significantly reduces the capacity of rat liver mitochondria to oxidize acetaldehyde. This is associated with decreased mitochondrial respiration with acetaldehyde as substrate. The reduced ability of mitochondria to metabolize acetaldehyde may explain the high levels of acetaldehyde in the blood of alcoholics, which in turn could promote the perpetuation of liver injury.

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Year:  1975        PMID： 168641     DOI： 10.1126/science.168641

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  9 in total

1.  Acute ethanol preexposure promotes liver regeneration after partial hepatectomy in mice by activating ALDH2.

Authors:  Xiang Ding; Juliane I Beier; Keegan J Baldauf; Jenny D Jokinen; Hai Zhong; Gavin E Arteel
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2013-10-31       Impact factor: 4.052

Review 2.  Pharmacokinetic and pharmacodynamic principles of illicit drug use and treatment of illicit drug users.

Authors:  D I Quinn; A Wodak; R O Day
Journal:  Clin Pharmacokinet       Date:  1997-11       Impact factor: 6.447

Review 3.  Alcohol and gamma-glutamyltransferase.

Authors:  M Nishimura; R Teschke
Journal:  Klin Wochenschr       Date:  1983-03-15

4.  Comparison of protection by L-ascorbic acid, L-cysteine, and adrenergic-blocking agents against acetaldehyde, acrolein, and formaldehyde toxicity: implications in smoking.

Authors:  H Sprince; C M Parker; G G Smith
Journal:  Agents Actions       Date:  1979-10

5.  Impaired acetaldehyde oxidation in alcoholics.

Authors:  K R Palmer; W J Jenkins
Journal:  Gut       Date:  1982-09       Impact factor: 23.059

6.  How does alcohol damage the liver?

Authors: 
Journal:  Br Med J       Date:  1978 Dec 23-30

7.  Ethanol-induced oxidative stress: basic knowledge.

Authors:  Mario Comporti; Cinzia Signorini; Silvia Leoncini; Concetta Gardi; Lucia Ciccoli; Anna Giardini; Daniela Vecchio; Beatrice Arezzini
Journal:  Genes Nutr       Date:  2009-12-24       Impact factor: 5.523

Review 8.  Molecular, Viral and Clinical Features of Alcohol- and Non-Alcohol-Induced Liver Injury.

Authors:  Manuela G Neuman; Helmut K Seitz; Rolf Teschke; Stephen Malnick; Kamisha L Johnson-Davis; Lawrence B Cohen; Anit German; Nicolas Hohmann; Bernhardo Moreira; George Moussa; Mihai Opris
Journal:  Curr Issues Mol Biol       Date:  2022-03-16       Impact factor: 2.976

Review 9.  Alcoholic Liver Disease: Current Mechanistic Aspects with Focus on Their Clinical Relevance.

Authors:  Rolf Teschke
Journal:  Biomedicines       Date:  2019-09-05
  9 in total

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