Literature DB >> 16862151

A potential molecular mechanism for hypersensitivity caused by formalin-inactivated vaccines.

Amin Moghaddam1, Wieslawa Olszewska, Belinda Wang, John S Tregoning, Rebecca Helson, Quentin J Sattentau, Peter J M Openshaw.   

Abstract

Heat, oxidation and exposure to aldehydes create reactive carbonyl groups on proteins, targeting antigens to scavenger receptors. Formaldehyde is widely used in making vaccines, but has been associated with atypical enhanced disease during subsequent infection with paramyxoviruses. We show that carbonyl groups on formaldehyde-treated vaccine antigens boost T helper type 2 (T(H)2) responses and enhance respiratory syncytial virus (RSV) disease in mice, an effect partially reversible by chemical reduction of carbonyl groups.

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Year:  2006        PMID： 16862151     DOI： 10.1038/nm1456

Source DB:  PubMed          Journal:  Nat Med        ISSN： 1078-8956            Impact factor:   53.440


  94 in total

1.  A double-inactivated severe acute respiratory syndrome coronavirus vaccine provides incomplete protection in mice and induces increased eosinophilic proinflammatory pulmonary response upon challenge.

Authors:  Meagan Bolles; Damon Deming; Kristin Long; Sudhakar Agnihothram; Alan Whitmore; Martin Ferris; William Funkhouser; Lisa Gralinski; Allison Totura; Mark Heise; Ralph S Baric
Journal:  J Virol       Date:  2011-09-21       Impact factor: 5.103

Review 2.  Recent vaccine development for human metapneumovirus.

Authors:  J Ren; T Phan; X Bao
Journal:  J Gen Virol       Date:  2015-02-09       Impact factor: 3.891

Review 3.  How innate immune mechanisms contribute to antibody-enhanced viral infections.

Authors:  Sukathida Ubol; Scott B Halstead
Journal:  Clin Vaccine Immunol       Date:  2010-09-28

4.  Fixing a failed vaccine.

Authors:  Steven M Varga
Journal:  Nat Med       Date:  2009-01       Impact factor: 53.440

5.  A critical role of Gas6/Axl signal in allergic airway responses during RSV vaccine-enhanced disease.

Authors:  Takehiko Shibata; Manabu Ato
Journal:  Immunol Cell Biol       Date:  2017-07-19       Impact factor: 5.126

6.  Defective immunoregulation in RSV vaccine-augmented viral lung disease restored by selective chemoattraction of regulatory T cells.

Authors:  Jens Loebbermann; Lydia Durant; Hannah Thornton; Cecilia Johansson; Peter J Openshaw
Journal:  Proc Natl Acad Sci U S A       Date:  2013-02-04       Impact factor: 11.205

7.  Protective T cell immunity against respiratory syncytial virus is efficiently induced by recombinant BCG.

Authors:  Susan M Bueno; Pablo A González; Kelly M Cautivo; Jorge E Mora; Eduardo D Leiva; Hugo E Tobar; Glenn J Fennelly; Eliseo A Eugenin; William R Jacobs; Claudia A Riedel; Alexis M Kalergis
Journal:  Proc Natl Acad Sci U S A       Date:  2008-12-15       Impact factor: 11.205

8.  Immunogenicity of a psoralen-inactivated dengue virus type 1 vaccine candidate in mice.

Authors:  Ryan C Maves; Roger M Castillo Oré; Kevin R Porter; Tadeusz J Kochel
Journal:  Clin Vaccine Immunol       Date:  2009-12-09

9.  C5 modulates airway hyperreactivity and pulmonary eosinophilia during enhanced respiratory syncytial virus disease by decreasing C3a receptor expression.

Authors:  Guillermina A Melendi; Scott J Hoffman; Ruth A Karron; Pablo M Irusta; Federico R Laham; Alison Humbles; Brian Schofield; Chien-Hsiung Pan; Richard Rabold; Bhagvanji Thumar; Adeep Thumar; Norma P Gerard; Wayne Mitzner; Scott R Barnum; Craig Gerard; Steven R Kleeberger; Fernando P Polack
Journal:  J Virol       Date:  2006-11-01       Impact factor: 5.103

10.  Alveolar macrophages are a major determinant of early responses to viral lung infection but do not influence subsequent disease development.

Authors:  Philippa K Pribul; James Harker; Belinda Wang; Hongwei Wang; John S Tregoning; Jürgen Schwarze; Peter J M Openshaw
Journal:  J Virol       Date:  2008-02-20       Impact factor: 5.103
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