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Literature DB >> 16861687

Swapping of periplasmic domains between Brucella suis VirB8 and a pSB102 VirB8 homologue allows heterologous complementation.

Gilles Patey¹, Zhong Qi, Gisele Bourg, Christian Baron, David O'Callaghan.

Abstract

A Brucella suis mutant with a nonpolar deletion in the virB8 gene was attenuated in a macrophage infection model. Complementation with the B. suis VirB8 protein expressed from the virB promoter restored virulence. Expression of TraJ, a VirB8 homologue from plasmid pSB102, did not restore virulence; however, virulence was partially restored by a chimeric protein containing the N terminus of the B. suis VirB8 protein and the C-terminal periplasmic domain of TraJ.

Entities: Disease Species

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Year: 2006 PMID： 16861687 PMCID： PMC1539617 DOI： 10.1128/IAI.00584-06

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

21 in total

1. Structures of two core subunits of the bacterial type IV secretion system, VirB8 from Brucella suis and ComB10 from Helicobacter pylori.

Authors: Laurent Terradot; Richard Bayliss; Clasien Oomen; Gordon A Leonard; Christian Baron; Gabriel Waksman
Journal: Proc Natl Acad Sci U S A Date: 2005-03-11 Impact factor: 11.205

Review 2. Biogenesis, architecture, and function of bacterial type IV secretion systems.

Authors: Peter J Christie; Krishnamohan Atmakuri; Vidhya Krishnamoorthy; Simon Jakubowski; Eric Cascales
Journal: Annu Rev Microbiol Date: 2005 Impact factor: 15.500

3. Identification of the VirB4-VirB8-VirB5-VirB2 pilus assembly sequence of type IV secretion systems.

Authors: Qing Yuan; Anna Carle; Chan Gao; Durga Sivanesan; Khaled Ahmed Aly; Christoph Höppner; Lilian Krall; Natalie Domke; Christian Baron
Journal: J Biol Chem Date: 2005-05-18 Impact factor: 5.157

4. The Brucella suis type IV secretion system assembles in the cell envelope of the heterologous host Agrobacterium tumefaciens and increases IncQ plasmid pLS1 recipient competence.

Authors: Anna Carle; Christoph Höppner; Khaled Ahmed Aly; Qing Yuan; Amke den Dulk-Ras; Annette Vergunst; David O'Callaghan; Christian Baron
Journal: Infect Immun Date: 2006-01 Impact factor: 3.441

5. Dimerization and interactions of Brucella suis VirB8 with VirB4 and VirB10 are required for its biological activity.

Authors: Athanasios Paschos; Gilles Patey; Durga Sivanesan; Chan Gao; Richard Bayliss; Gabriel Waksman; David O'callaghan; Christian Baron
Journal: Proc Natl Acad Sci U S A Date: 2006-04-28 Impact factor: 11.205

6. Subcellular localization of the Agrobacterium tumefaciens T-DNA transport pore proteins: VirB8 is essential for the assembly of the transport pore.

Authors: R B Kumar; Y H Xie; A Das
Journal: Mol Microbiol Date: 2000-05 Impact factor: 3.501

7. Early acidification of phagosomes containing Brucella suis is essential for intracellular survival in murine macrophages.

Authors: F Porte; J P Liautard; S Köhler
Journal: Infect Immun Date: 1999-08 Impact factor: 3.441

8. TraC of IncN plasmid pKM101 associates with membranes and extracellular high-molecular-weight structures in Escherichia coli.

Authors: H Schmidt-Eisenlohr; N Domke; C Baron
Journal: J Bacteriol Date: 1999-09 Impact factor: 3.490

9. Spatial location and requirements for the assembly of the Agrobacterium tumefaciens type IV secretion apparatus.

Authors: Paul K Judd; Renu B Kumar; Anath Das
Journal: Proc Natl Acad Sci U S A Date: 2005-08-02 Impact factor: 11.205

10. Agrobacterium tumefaciens VirB8 structure reveals potential protein-protein interaction sites.

Authors: Susan Bailey; Doyle Ward; Rebecca Middleton; J Gunter Grossmann; Patricia C Zambryski
Journal: Proc Natl Acad Sci U S A Date: 2006-02-15 Impact factor: 11.205

16 in total

1. Structural Analysis and Inhibition of TraE from the pKM101 Type IV Secretion System.

Authors: Bastien Casu; Jonathan Smart; Mark A Hancock; Mark Smith; Jurgen Sygusch; Christian Baron
Journal: J Biol Chem Date: 2016-09-15 Impact factor: 5.157

2. An in vivo high-throughput screening approach targeting the type IV secretion system component VirB8 identified inhibitors of Brucella abortus 2308 proliferation.

Authors: Athanasios Paschos; Andreas den Hartigh; Mark A Smith; Vidya L Atluri; Durga Sivanesan; Renée M Tsolis; Christian Baron
Journal: Infect Immun Date: 2010-12-20 Impact factor: 3.441

3. The dimer interface of Agrobacterium tumefaciens VirB8 is important for type IV secretion system function, stability, and association of VirB2 with the core complex.

Authors: Durga Sivanesan; Christian Baron
Journal: J Bacteriol Date: 2011-03-11 Impact factor: 3.490

4. Identification of VceA and VceC, two members of the VjbR regulon that are translocated into macrophages by the Brucella type IV secretion system.

Authors: Maarten F de Jong; Yao-Hui Sun; Andreas B den Hartigh; Jan Maarten van Dijl; Renée M Tsolis
Journal: Mol Microbiol Date: 2008-10-24 Impact factor: 3.501

5. VirB3 to VirB6 and VirB8 to VirB11, but not VirB7, are essential for mediating persistence of Brucella in the reticuloendothelial system.

Authors: Andreas B den Hartigh; Hortensia G Rolán; Maarten F de Jong; Renée M Tsolis
Journal: J Bacteriol Date: 2008-05-09 Impact factor: 3.490

6. The Twin-Arginine Translocation System Is Important for Stress Resistance and Virulence of Brucella melitensis.

Authors: Xin Yan; Sen Hu; Yan Yang; Da Xu; Huoming Li; Wenxing Liu; Xijun He; Ganwu Li; Wentong Cai; Zhigao Bu
Journal: Infect Immun Date: 2020-10-19 Impact factor: 3.441

7. Interactions between Brucella suis VirB8 and its homolog TraJ from the plasmid pSB102 underline the dynamic nature of type IV secretion systems.

Authors: Gisèle Bourg; Romain Sube; David O'Callaghan; Gilles Patey
Journal: J Bacteriol Date: 2009-02-27 Impact factor: 3.490