Literature DB >> 16861146

Evidence for "Unertan Syndrome" and the evolution of the human mind.

Uner Tan1.   

Abstract

A new family exhibiting "Unertan Sydnrome" was discovered. The pedigree analysis showed marriages between relatives. This family was similar to the first one (see Tan, 2006a), providing a firm evidence for the new syndrome. The affected children showed habitual quadrupedal walking gait, that is, they walked on wrists and feet with straight legs and arms. Their heads and bodies were mildly flexed; they exhibited mild cerebellar signs, and severe mental retardation. The pedigree demonstrated a typical autosomal-recessive inheritance. The genetic nature of this syndrome suggests a backward stage in human evolution (devolution), which would be consistent with theories of punctuated evolution. The results reflected a new theory on the evolution of human beings. That is, the evolution of humans would in fact be the evolution of the extensor motor system, responsible for upright posture, against the gravitational forces. This would be coupled with the emergence of the human mind, which can be considered a reflexion of the human motor system, in accord with the psychomotor theory (see Tan, 2005a). The most important characteristic of the newly emerged human mind was the resistance against gravitational forces. This was the resistive mind, the origins of human creativity.

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Year:  2006        PMID: 16861146     DOI: 10.1080/00207450600588733

Source DB:  PubMed          Journal:  Int J Neurosci        ISSN: 0020-7454            Impact factor:   2.292


  8 in total

1.  Missense mutation in the ATPase, aminophospholipid transporter protein ATP8A2 is associated with cerebellar atrophy and quadrupedal locomotion.

Authors:  Onur Emre Onat; Suleyman Gulsuner; Kaya Bilguvar; Ayse Nazli Basak; Haluk Topaloglu; Meliha Tan; Uner Tan; Murat Gunel; Tayfun Ozcelik
Journal:  Eur J Hum Genet       Date:  2012-08-15       Impact factor: 4.246

2.  Mutations in the very low-density lipoprotein receptor VLDLR cause cerebellar hypoplasia and quadrupedal locomotion in humans.

Authors:  Tayfun Ozcelik; Nurten Akarsu; Elif Uz; Safak Caglayan; Suleyman Gulsuner; Onur Emre Onat; Meliha Tan; Uner Tan
Journal:  Proc Natl Acad Sci U S A       Date:  2008-03-07       Impact factor: 11.205

3.  Central pattern generator for locomotion: anatomical, physiological, and pathophysiological considerations.

Authors:  Pierre A Guertin
Journal:  Front Neurol       Date:  2013-02-08       Impact factor: 4.003

4.  Uner tan syndrome: history, clinical evaluations, genetics, and the dynamics of human quadrupedalism.

Authors:  Uner Tan
Journal:  Open Neurol J       Date:  2010-07-16

Review 5.  Two families with quadrupedalism, mental retardation, no speech, and infantile hypotonia (Uner Tan Syndrome Type-II); a novel theory for the evolutionary emergence of human bipedalism.

Authors:  Uner Tan
Journal:  Front Neurosci       Date:  2014-04-22       Impact factor: 4.677

Review 6.  Preclinical evidence supporting the clinical development of central pattern generator-modulating therapies for chronic spinal cord-injured patients.

Authors:  Pierre A Guertin
Journal:  Front Hum Neurosci       Date:  2014-05-30       Impact factor: 3.169

7.  Human quadrupeds, primate quadrupedalism, and Uner Tan Syndrome.

Authors:  Liza J Shapiro; Whitney G Cole; Jesse W Young; David A Raichlen; Scott R Robinson; Karen E Adolph
Journal:  PLoS One       Date:  2014-07-16       Impact factor: 3.240

8.  Further Delineation of the Clinical Phenotype of Cerebellar Ataxia, Mental Retardation, and Disequilibrium Syndrome Type 4.

Authors:  Saud Alsahli; Muhammad Talal Alrifai; Saeed Al Tala; Fuad Al Mutairi; Majid Alfadhel
Journal:  J Cent Nerv Syst Dis       Date:  2018-02-28
  8 in total

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