| Literature DB >> 16860406 |
Nikolaos Pitsikas1, Nikolaos Sakellaridis.
Abstract
The effects of extracts of Crocus sativus L. (CSE), on memory were investigated in the rat by using the object recognition and the step-through passive avoidance task. In the first study, post-training administration of CSE (30 and 60 g/kg) successfully counteracted extinction of recognition memory in the normal rat, suggesting that CSE modulates storage and/or retrieval of information. In a subsequent study, pre-training treatment with CSE (30 and 60 mg/kg) significantly antagonized the scopolamine (0.75 mg/kg)-induced performance deficits in the step-through passive avoidance test. These results support and extend prior findings about the implication of CSE in learning and memory mechanisms.Entities:
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Year: 2006 PMID： 16860406 DOI： 10.1016/j.bbr.2006.06.005
Source DB: PubMed Journal: Behav Brain Res ISSN： 0166-4328 Impact factor: 3.332