Literature DB >> 29531865

The protective effects of crocin in the management of neurodegenerative diseases: a review.

Tahereh Farkhondeh1, Saeed Samarghandian2, Hanieh Shaterzadeh Yazdi3, Fariborz Samini4.   

Abstract

Flavonoids have been used in traditional medicine to promote human health. Crocin has been proposed to be effective in the management of the various diseases including the neurodegenerative diseases. Antiepileptic and anti-Alzheimer effects of crocin have also been indicated. The efficacy of crocis in the treatment of cerebral ischemia and traumatic brain injury was also confirmed by using animal models. Crocin treatment increased dopamine levels in the brain of experimental model of Parkinson's disease. In addition, crocin modulates the opioid system to decrease the withdrawal syndrome. Thus, the present study highlighted the effects of crocin on the nervous system and the underling mechanisms. This review also indicated that crocins can be considered as an effective candidate in the management of nervous system diseases due to their antioxidant and anti-inflammation effects.

Entities:  

Keywords:  Crocins; anti-inflammation; antioxidant; nervous system

Year:  2018        PMID： 29531865      PMCID： PMC5840286     

Source DB:  PubMed          Journal:  Am J Neurodegener Dis        ISSN： 2165-591X


  62 in total

1.  Anti-inflammatory effects of crocin and crocetin in rat brain microglial cells.

Authors:  Kyong Nyon Nam; Young-Min Park; Hoon-Ji Jung; Jung Yeon Lee; Byung Duk Min; Seong-Uk Park; Woo-Sang Jung; Ki-Ho Cho; Ji-Ho Park; Insug Kang; Joung-Woo Hong; Eunjoo H Lee
Journal:  Eur J Pharmacol       Date:  2010-09-18       Impact factor: 4.432

2.  Effect of chrysin on nociception in formalin test and serum levels of noradrenalin and corticosterone in rats.

Authors:  Tahereh Farkhondeh; Saeed Samarghandian; Mohsen Azimin-Nezhad; Fariborz Samini
Journal:  Int J Clin Exp Med       Date:  2015-02-15

3.  Effects of crocin on reperfusion-induced oxidative/nitrative injury to cerebral microvessels after global cerebral ischemia.

Authors:  Yong-Qiu Zheng; Jian-Xun Liu; Jan-Nong Wang; Li Xu
Journal:  Brain Res       Date:  2006-12-29       Impact factor: 3.252

4.  Crocin suppresses tumor necrosis factor-alpha-induced cell death of neuronally differentiated PC-12 cells.

Authors:  S Soeda; T Ochiai; L Paopong; H Tanaka; Y Shoyama; H Shimeno
Journal:  Life Sci       Date:  2001-11-02       Impact factor: 5.037

5.  Crocin Upregulates CX3CR1 Expression by Suppressing NF-κB/YY1 Signaling and Inhibiting Lipopolysaccharide-Induced Microglial Activation.

Authors:  Bochang Lv; Fuquan Huo; Zhongqiao Zhu; Zhiguo Xu; Xiaojie Dang; Tao Chen; Ting Zhang; Xinguang Yang
Journal:  Neurochem Res       Date:  2016-04-15       Impact factor: 3.996

Review 6.  Consciousness loss during epileptogenesis: implication for VLPO-PnO circuits.

Authors:  Maohui Feng; Zhigang He; Baowen Liu; Zhixiao Li; Guorong Tao; Duozhi Wu; Hongbing Xiang
Journal:  Int J Physiol Pathophysiol Pharmacol       Date:  2017-02-15

7.  Influence of N-acetyl cysteine on beta-amyloid-induced Alzheimer's disease in a rat model: A behavioral and electrophysiological study.

Authors:  Siamak Shahidi; Somayeh Zargooshnia; Sara Soleimani Asl; Alireza Komaki; Abdolrahman Sarihi
Journal:  Brain Res Bull       Date:  2017-04-11       Impact factor: 4.077

8.  Crocin protects PC12 cells against MPP(+)-induced injury through inhibition of mitochondrial dysfunction and ER stress.

Authors:  Guo-Feng Zhang; Yi Zhang; Gang Zhao
Journal:  Neurochem Int       Date:  2015-07-21       Impact factor: 3.921

9.  Protective Effects of Crocus Sativus L. Extract and Crocin against Chronic-Stress Induced Oxidative Damage of Brain, Liver and Kidneys in Rats.

Authors:  Ahmad Reza Bandegi; Ali Rashidy-Pour; Abbas Ali Vafaei; Behshid Ghadrdoost
Journal:  Adv Pharm Bull       Date:  2014-12-31

10.  Protective effect of crocin on acrolein-induced tau phosphorylation in the rat brain.

Authors:  Marzieh Rashedinia; Parisa Lari; Khalil Abnous; Hossein Hosseinzadeh
Journal:  Acta Neurobiol Exp (Wars)       Date:  2015       Impact factor: 1.579
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  6 in total

Review 1.  Nootropic and Anti-Alzheimer's Actions of Medicinal Plants: Molecular Insight into Therapeutic Potential to Alleviate Alzheimer's Neuropathology.

Authors:  Md Sahab Uddin; Abdullah Al Mamun; Md Tanvir Kabir; Md Jakaria; Bijo Mathew; George E Barreto; Ghulam Md Ashraf
Journal:  Mol Neurobiol       Date:  2018-11-09       Impact factor: 5.590

2.  Moderating effects of crocin on some stress oxidative markers in rat brain following demyelination with ethidium bromide.

Authors:  Hadi Fathimoghadam; Yaghoub Farbod; Ataallah Ghadiri; Rouholah Fatemi
Journal:  Heliyon       Date:  2019-02-15

Review 3.  A systematic review of treatment for patients with burning mouth syndrome.

Authors:  Huann Lan Tan; Jared G Smith; Jan Hoffmann; Tara Renton
Journal:  Cephalalgia       Date:  2021-08-18       Impact factor: 6.292

Review 4.  Potential Role of Phytochemical Extract from Saffron in Development of Functional Foods and Protection of Brain-Related Disorders.

Authors:  Zahra Maqbool; Muhammad Sajid Arshad; Anwar Ali; Afifa Aziz; Waseem Khalid; Muhammad Faizan Afzal; Sneh Punia Bangar; Mohamed Addi; Christophe Hano; Jose Manuel Lorenzo
Journal:  Oxid Med Cell Longev       Date:  2022-09-22       Impact factor: 7.310

5.  Genome-Wide Characterization and Analysis of bHLH Transcription Factors Related to Crocin Biosynthesis in Gardenia jasminoides Ellis (Rubiaceae).

Authors:  Ya Tian; Xiangdong Pu; Haoying Yu; Aijia Ji; Ranran Gao; Yating Hu; Zhichao Xu; Hualei Wang
Journal:  Biomed Res Int       Date:  2020-04-06       Impact factor: 3.411

6.  Saffron extract and crocin exert anti-inflammatory and anti-oxidative effects in a repetitive mild traumatic brain injury mouse model.

Authors:  Marwa Salem; Mariam Shaheen; Abeer Tabbara; Jamilah Borjac
Journal:  Sci Rep       Date:  2022-03-23       Impact factor: 4.379
  6 in total

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