AIM: To study efficacy and acceptability of tianeptine in treatment of depression in patients with myocardial infarction (MI). MATERIAL AND METHODS: A group of 416 patients (253 men and 163 women) from 35 till 89 years old with MI was studied. Depression was diagnosed in 113 of them (27.2 %) by the use of Zung depression scale and CD-10 criteria. Tianeptine treatment was given to 55 patients (25-37.5 mg/day for 3.3 months), 58 patients were in control group. RESULTS: Tianeptine treatment of depression in patients with MI in 3-7 days led to decrease of feeling of depression and lowering of anxiety. Depression decreased in 9.4% patients of this group in 2 months. After 2 months depression was diagnosed in 55.7 % of patients who did not receive the antidepressant. During 1 year patients, who were treated by tianeptine, had 31% lower number of hospitalizations due to exacerbations of cardiovascular diseases. Patients had a good tolerance of tianeptine treatment independently of age. CONCLUSION: Tianeptine treatment of depression in patients with MI is effective, safe, well tolerated by patients and allows to decrease number of hospitalizations because of complications of cardiovascular diseases during 1 year.
AIM: To study efficacy and acceptability of tianeptine in treatment of depression in patients with myocardial infarction (MI). MATERIAL AND METHODS: A group of 416 patients (253 men and 163 women) from 35 till 89 years old with MI was studied. Depression was diagnosed in 113 of them (27.2 %) by the use of Zung depression scale and CD-10 criteria. Tianeptine treatment was given to 55 patients (25-37.5 mg/day for 3.3 months), 58 patients were in control group. RESULTS:Tianeptine treatment of depression in patients with MI in 3-7 days led to decrease of feeling of depression and lowering of anxiety. Depression decreased in 9.4% patients of this group in 2 months. After 2 months depression was diagnosed in 55.7 % of patients who did not receive the antidepressant. During 1 year patients, who were treated by tianeptine, had 31% lower number of hospitalizations due to exacerbations of cardiovascular diseases. Patients had a good tolerance of tianeptine treatment independently of age. CONCLUSION:Tianeptine treatment of depression in patients with MI is effective, safe, well tolerated by patients and allows to decrease number of hospitalizations because of complications of cardiovascular diseases during 1 year.